Evidence map›Paper›PMID 33087465›Full record

ArticleJournal of virology2021

CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts.

Seiichi Kato, Hisatoshi Shida, Tomotaka Okamura, Xianfeng Zhang, Tomoyuki Miura, Tetsu Mukai, Makoto Inoue, Tsugumine Shu, Taeko K Naruse, Akinori Kimura and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. RecombinantVaccines · 2025
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Seiichi KatoTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Hisatoshi ShidaInstitute for Genetic Medicine, Hokkaido University, Sapporo, Japan hmyy2010@yahoo.co.jp matsuo@bcg.gr.jp.
Tomotaka OkamuraTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Xianfeng ZhangInstitute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Tomoyuki MiuraInstitute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Tetsu MukaiLeprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Makoto InoueID Pharma Co., Ltd., Ibaraki, Japan.
Tsugumine ShuID Pharma Co., Ltd., Ibaraki, Japan.
Taeko K NaruseTokyo Medical and Dental University, Tokyo, Japan.
Akinori KimuraTokyo Medical and Dental University, Tokyo, Japan.
Yasuhiro YasutomiTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Kazuhiro MatsuoResearch & Development Department, Japan BCG Laboratory, Tokyo, Japan hmyy2010@yahoo.co.jp matsuo@bcg.gr.jp.ORCID 0000-0002-2329-887X
National Institute of Biomedical Innovation, Health and Nutrition · JPHokkaido University · JPID Pharma (Japan) · JPTokyo Medical and Dental University · JPJapan BCG Laboratory · JPKyoto University · JPNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toward development of a dual vaccine for human immunodeficiency virus type 1 (HIV-1) and tuberculosis infections, we developed a urease-deficient bacillus Calmette-Guérin (BCG) strain Tokyo172 (BCGΔurease) to enhance its immunogenicity. BCGΔurease expressing a simian immunodeficiency virus (SIV) Gag induced BCG antigen-specific CD4

Indexed as

Acquired Immunodeficiency SyndromeAIDS VaccinesAnimalsBCG VaccineCD8-Positive T-LymphocytesCell LineCricetinaeDisease Models, AnimalGenetic VectorsHIV-1HumansMacaca mulattaMiceMice, Inbred C57BLRabbitsSAIDS VaccinesAIDS VaccinesBCG VaccineSAIDS VaccinesCTLHIVhuman immunodeficiency virusrecombinant BCGrecombinant vacciniasimian immunodeficiency virusSIV

Identifiers

PMID33087465
PMCPMC7851566
OpenAlexW3093972976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.