ArticleJournal of virology2020
Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4
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Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 34 citations in OpenAlex.
- The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Quantification and localization of integrated HIV-1 in memory and naïve CD4+ T cells from adolescents and young adults with perinatally-acquired HIV-1.PLoS pathogens · 2026Article
- The Importance of Pediatric Nonhuman Primate Models in Translational HIV Research.Journal of medical primatology · 2026Review
- Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption.Science translational medicine · 2025Article
- Impact of Delayed Early Antiretroviral Therapy Initiation on Treatment Outcomes in Infant Macaques Exposed to SHIVAD8.Viruses · 2025Article
- SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques.PLoS pathogens · 2025Article
- A gut check: understanding the interplay of the gastrointestinal microbiome and the developing immune system towards the goal of pediatric HIV remission.Retrovirology · 2024Review
- Article
- Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques.bioRxiv : the preprint server for biology · 2024Article
- Comparative analysis of within-host dynamics of acute infection and viral rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques.bioRxiv : the preprint server for biology · 2024Article
- More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure.Current HIV/AIDS reports · 2024Review
- Article
- Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024Review
- Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure.AIDS research and human retroviruses · 2023Article
- Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterisation of HIV-1 reservoirs in paediatric populations: protocol for a systematic review and meta-analysis.BMJ open · 2023Article
- A simple model for viral decay dynamics and the distribution of infected cell life spans in SHIV-infected infant rhesus macaques.Mathematical biosciences · 2023Article
- Immune activation and exhaustion marker expression on T-cell subsets in ART-treated adolescents and young adults with perinatal HIV-1 infection as correlates of viral persistence.Frontiers in immunology · 2023Article
- Animal models for studies of HIV-1 brain reservoirs.Journal of leukocyte biology · 2022Review
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Authors and funding
21 authors at 6 institutions in 1 country.
Veronica Obregon-PerkoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Katherine M BrickerDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Gloria MensahDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Ferzan UddinDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Mithra R KumarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Emily J FrayDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nils SchoofDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Anna HornerDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Maud MavignerDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-9898-317X
Shan LiangYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Thomas VanderfordYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Julian SassDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.
Cliburn ChanDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.
Stella J BerendamDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Katharine J BarPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
George M ShawPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Guido SilvestriYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Genevieve G FoudaDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0002-0960-1019
Sallie R PermarDuke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA achahro@emory.edu.ORCID 0000-0001-7479-9546
Emory University · USDuke Medical Center · USDuke University · USJohns Hopkins University · USUniversity of Pennsylvania · USHoward Hughes Medical Institute · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0MSocial and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5MWinship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5MVirus and Antibody Gene Sequencing CoreP01AI131251 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Kevin Wiehe · 2017 to 2026
$40.7MRuth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8MProject !: Differential contribution of resting CD4+ T cells and resident macrophages to viral rebound after antiretroviral treatment interruptionP01AI131306 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, MANKOWSKI, JOSEPH L · 2017 to 2021
$8.5MThe origin, predictors, and immune correlates of viral rebound in orally SHIV infected infant monkeysP01AI131276 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI PERMAR, SALLIE R. · 2017 to 2021
$8.3MTraining a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4MTargeting 5' leader-encoded defective ribosomal products for HIV T cell vaccinesR01AI118549 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHAW, GEORGE M · 2016 to 2020
$3.6MbNAb induction by antigenically diverse V1V2 lineage specific SHIVs and SOSIPsR01AI131331 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHAW, GEORGE M · 2017 to 2020
$3.2MNCI NIH HHS P30 CA138292NIAID NIH HHS P01 AI131251NIAID NIH HHS P01 AI131276NIAID NIH HHS P01 AI131306NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI118549NIAID NIH HHS R01 AI131331NIAID NIH HHS T32 AI007392NIAID NIH HHS T32 AI074492NIH HHS P51 OD011132
Abstract
Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) continues to cause new pediatric cases of infection through breastfeeding, a setting where it is not always possible to initiate early antiretroviral therapy (ART). Without novel interventions that do not rely on daily ART, HIV-1-infected children face lifelong medications to control infection. A detailed analysis of virus persistence following breast milk transmission of HIV-1 and ART has not been performed. Here, we used infant rhesus macaques orally infected with simian/human immunodeficiency virus (SHIV) (SHIV.C.CH505) to identify cellular and anatomical sites of virus persistence under ART. Viral DNA was detected at similar levels in blood and tissue CD4
Indexed as
Macaca mulattaAdministration, OralAnimalsAnimals, NewbornAnti-Retroviral AgentsCD4-Positive T-LymphocytesDisease ReservoirsDNA, ViralFemaleHIV-1HIV InfectionsMaleMonkey DiseasesReassortant VirusesRNA, ViralSimian Acquired Immunodeficiency SyndromeAnti-Retroviral AgentsDNA, ViralRNA, Viralcurehuman immunodeficiency virusnonhuman primatespediatricreservoir
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.