Evidence map›Paper›PMID 33087357›Full record

ArticleScience advances2020

CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation.

Shan Cui, Chenhui Wang, Weizhi Bai, Jiao Li, Yue Pan, Xiaoyong Huang, Han Yang, Zeqing Feng, Qun Xiang, Lei Fei and 5 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. mBio · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Shan CuiYanbian University Hospital, Yanbian University, Jilin Province 133000, People's Republic of China.ORCID 0000-0002-9328-0093
Chenhui WangInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.ORCID 0000-0002-7527-4028
Weizhi BaiDepartment of Emergency, Chongqing University Center Hospital, Chongqing Emergency Medical Center, Chongqing 400038, People's Republic of China.ORCID 0000-0002-3215-8414
Jiao LiSchool of Medicine, Yanbian University, Jilin Province 133000, People's Republic of China.ORCID 0000-0002-0323-3710
Yue PanInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.ORCID 0000-0002-0926-2846
Xiaoyong HuangInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.
Han YangInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.
Zeqing FengInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.ORCID 0000-0001-9424-867X
Qun XiangInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.
Lei FeiInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China.
Lixin ZhengLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Jian HuangDepartment of Emergency, Chongqing University Center Hospital, Chongqing Emergency Medical Center, Chongqing 400038, People's Republic of China. chenyongwen@tmmu.edu.cn wuyuzhang@tmmu.edu.cn zqg0621@ybu.edu.cn 85408306@qq.com.ORCID 0000-0002-3215-8414
Qinggao ZhangSchool of Medicine, Yanbian University, Jilin Province 133000, People's Republic of China. chenyongwen@tmmu.edu.cn wuyuzhang@tmmu.edu.cn zqg0621@ybu.edu.cn 85408306@qq.com.ORCID 0000-0002-7140-3822
Yuzhang WuInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China. chenyongwen@tmmu.edu.cn wuyuzhang@tmmu.edu.cn zqg0621@ybu.edu.cn 85408306@qq.com.ORCID 0000-0002-5948-1596
Yongwen ChenInstitute of Immunology, PLA, Third Military Medical University, Chongqing 400038, People's Republic of China. chenyongwen@tmmu.edu.cn wuyuzhang@tmmu.edu.cn zqg0621@ybu.edu.cn 85408306@qq.com.ORCID 0000-0003-0022-6627
Army Medical University · CNChongqing Emergency Medical Center · CNYanbian University · CNNational Institute of Allergy and Infectious Diseases · USYanbian University Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of immune responses in the gut often associates with inflammatory bowel diseases (IBD). Mouse CD1d1, an ortholog of human CD1d mainly participating in lipid-antigen presentation to NKT cells, is able to generate intrinsic signals upon stimulation. Mice with macrophage-specific

Indexed as

ColitisInflammatory Bowel DiseasesAnimalsDextran SulfateInflammasomesInflammationMacrophagesMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinDextran SulfateInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse

Identifiers

PMID33087357
PMCPMC7577718
OpenAlexW3094590694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.