Evidence map›Paper›PMID 33087346›Full record

ArticleScience advances2020

The structural basis for Z α

Sarah V Faull, Emma L K Elliston, Bibek Gooptu, Alistair M Jagger, Ibrahim Aldobiyan, Adam Redzej, Magd Badaoui, Nina Heyer-Chauhan, S Tamir Rashid, Gary M Reynolds and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. The mechanism of pathogenic αProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Sarah V FaullUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK.ORCID 0000-0002-3496-8488
Emma L K EllistonUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK.ORCID 0000-0002-6768-9645
Bibek GooptuLeicester Institute of Structural and Chemical Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 7HB, UK.ORCID 0000-0002-5223-1121
Alistair M JaggerUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK.ORCID 0000-0001-9680-254X
Ibrahim AldobiyanUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK.
Adam RedzejInstitute of Structural and Molecular Biology, Birkbeck College, Malet Street, University of London, London WC1E 7HX, UK.ORCID 0000-0003-2471-289X
Magd BadaouiUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK.ORCID 0000-0001-9521-6696
Nina Heyer-ChauhanUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK.ORCID 0000-0002-3500-9174
S Tamir RashidCentre for Stem Cells and Regenerative Medicine and Institute for Liver Studies, King's College London, London WC2R 2LS, UK.ORCID 0000-0001-6779-2506
Gary M ReynoldsCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID 0000-0002-3250-0582
David H AdamsCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.ORCID 0000-0001-6776-0336
Elena MirandaDepartment of Biology and Biotechnologies "Charles Darwin" and Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
Elena V OrlovaInstitute of Structural and Molecular Biology, Birkbeck College, Malet Street, University of London, London WC1E 7HX, UK.ORCID 0000-0003-3371-415X
James A IrvingUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK. j.irving@ucl.ac.uk d.lomas@ucl.ac.uk.ORCID 0000-0003-3204-6356
David A LomasUCL Respiratory, University College London, 5 University Street, London WC1E 6JF, UK. j.irving@ucl.ac.uk d.lomas@ucl.ac.uk.ORCID 0000-0003-2339-6979
Institute of Structural and Molecular Biology · GBBirkbeck, University of London · GBNIHR Birmingham Liver Biomedical Research Unit · GBUniversity College London · GBInstitute for Stem Cell Biology and Regenerative Medicine · INIstituto Pasteur · ITUniversity of Leicester · GB

Funding

Medical Research Council MR/N024842/1Wellcome Trust
6 · The paper itself

Abstract

The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. α

Identifiers

PMID33087346
PMCPMC7577719
OpenAlexW3094369834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.