Evidence map›Paper›PMID 33087324›Full record

ArticleCancer research2020

Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling.

Deepak Parashar, Bindu Nair, Anjali Geethadevi, Jasmine George, Ajay Nair, Shirng-Wern Tsaih, Ishaque P Kadamberi, Gopa Kumar Gopinadhan Nair, Yiling Lu, Ramani Ramchandran and 6 more

Open access · greenAbstract read
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

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  20. FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1.Journal of cellular and molecular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Deepak Parashar *Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-5062-8950
Bindu Nair *Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0003-4521-5614
Anjali GeethadeviDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0001-5486-7919
Jasmine GeorgeDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ajay NairDepartment of Systems Biology, Columbia University, New York, New York.ORCID 0000-0003-4521-5614
Shirng-Wern TsaihDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-9836-4659
Ishaque P KadamberiDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Gopa Kumar Gopinadhan NairDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-2694-8401
Yiling LuDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ramani RamchandranDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-3555-6119
Denise S UyarDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-6081-0799
Janet S RaderDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0001-7031-3385
Prahlad T RamDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Gordon B MillsDepartment of Developmental and Cancer Biology, Knight Cancer Institute Oregon Health Science University, Oregon, Portland, Oregon.ORCID 0000-0002-0144-9614
Sunila PradeepDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin. pchaluvally@mcw.edu spradeep@mcw.edu.ORCID 0000-0003-2441-7727
Pradeep Chaluvally-RaghavanDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin. pchaluvally@mcw.edu spradeep@mcw.edu.
Medical College of Wisconsin · USThe University of Texas MD Anderson Cancer Center · USColumbia University · USOregon Health & Science University · US

Funding

U.T. M. D. Anderson Cancer Center SPORE in Ovarian CancerP50CA217685 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C, SOOD, ANIL K · 2017 to 2021
$7.9M
Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6M
The Role of Aberrant Splicing of EVl1 in Ovarian Cancer PathophysiologyR01CA123219 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLS, GORDON B., NANJUNDAN, MEERA · 2008 to 2012
$2.2M
Role of RNA activation in Tumor Progression and MetastasisR01CA229907 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI CHALUVALLY-RAGHAVAN, PRADEEP · 2019 to 2023
$1.7M
Functional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726k
NCI NIH HHS P50 CA217685NCI NIH HHS R01 CA123219NCI NIH HHS R01 CA229907NCI NIH HHS R50 CA221675NCI NIH HHS U01 CA217842
6 · The paper itself

Abstract

Peritoneal spread is the primary mechanism of metastasis of ovarian cancer, and survival of ovarian cancer cells in the peritoneal cavity as nonadherent spheroids and their adherence to the mesothelium of distant organs lead to cancer progression, metastasis, and mortality. However, the mechanisms that govern this metastatic process in ovarian cancer cells remain poorly understood. In this study, we cultured ovarian cancer cell lines in adherent and nonadherent conditions

Indexed as

AnimalsCell Line, TumorCell ProliferationCell SurvivalDisease Models, AnimalErb-b2 Receptor Tyrosine KinasesErbB ReceptorsFemaleForkhead Box Protein M1Gene Knockdown TechniquesHumansLapatinibMiceOvarian NeoplasmsPeritoneal NeoplasmsSignal TransductionEGFR protein, humanEGFR protein, mouseERBB2 protein, humanErbb2 protein, mouseErb-b2 Receptor Tyrosine KinasesErbB ReceptorsForkhead Box Protein M1FOXM1 protein, humanFoxm1 protein, mouseLapatinibThiostrepton

Identifiers

PMID33087324
PMCPMC7744365
OpenAlexW3094031749

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.