Evidence map›Paper›PMID 33087319›Full record

ArticleDiabetes care2020

Association of Maternal Prepregnancy Diabetes and Gestational Diabetes Mellitus With Congenital Anomalies of the Newborn.

Yuxiao Wu, Buyun Liu, Yangbo Sun, Yang Du, Mark K Santillan, Donna A Santillan, Linda G Snetselaar, Wei Bao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  10. [Management of hyperglycemia in pregnancy (Update 2026)].Wiener klinische Wochenschrift · 2026
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuxiao WuDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA.
Buyun LiuDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA.
Yangbo SunDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA.
Yang DuDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA wei-bao@uiowa.edu.
Mark K SantillanDepartment of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.
Donna A SantillanDepartment of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.
Linda G SnetselaarDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA.ORCID 0000-0002-6615-0779
Wei BaoDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA wei-bao@uiowa.edu.ORCID 0000-0002-7301-5786

Funding

Vasopressin and Preeclampsia: Early Mechanisms for PreventionR01HD089940 · NICHD · UNIVERSITY OF IOWA · PI SANTILLAN, MARK K · 2019 to 2023
$1.9M
Pregnancy-associated microRNAs in plasma as predictors of gestational diabetesR21HD091458 · NICHD · UNIVERSITY OF IOWA · PI BAO, WEI · 2017 to 2018
$419k
NICHD NIH HHS R01 HD089940NICHD NIH HHS R21 HD091458
6 · The paper itself

Abstract

objectiveTo examine the association of maternal prepregnancy diabetes, gestational diabetes mellitus (GDM), and 12 subtypes of congenital anomalies of the newborn. RESEARCH DESIGN AND

methodsWe included 29,211,974 live births with maternal age ranging from 18 to 49 years old documented in the National Vital Statistics System in the U.S. from 2011 to 2018. Information on prepregnancy diabetes, GDM, and congenital anomalies was retrieved from birth certificates. Log-binomial regression was used to estimate risk ratios (RRs) and 95% CIs for congenital anomalies overall and by subtypes.

resultsOf the 29,211,974 live births, there were 90,061 infants who had congenital anomalies identified at birth. The adjusted RRs of congenital anomalies at birth were 2.44 (95% CI 2.33-2.55) for prepregnancy diabetes and 1.28 (95% CI 1.24-1.31) for GDM. The associations were generally consistent across subgroups by maternal age, race/ethnicity, prepregnancy obesity status, and infant sex. For specific subtypes of congenital anomalies, maternal prepregnancy diabetes or GDM was associated with an increased risk of most subtypes. For example, the adjusted RRs of cyanotic congenital heart disease were 4.61 (95% CI 4.28-4.96) for prepregnancy diabetes and 1.50 (95% CI 1.43-1.58) for GDM; the adjusted RRs of hypospadias were 1.88 (95% CI 1.67-2.12) for prepregnancy diabetes and 1.29 (95% CI 1.21-1.36) for GDM.

conclusionsPrepregnancy diabetes and, to a lesser extent, GDM were associated with several subtypes of congenital anomalies of the newborn. These findings suggest potential benefits of preconception counseling in women with preexisting diabetes or at risk for GDM for the prevention of congenital anomalies.

Indexed as

AdolescentAdultCongenital AbnormalitiesDiabetes, GestationalFemaleHumansInfant, NewbornMaleMiddle AgedPregnancyPregnancy in DiabeticsPregnancy RateRisk FactorsYoung Adult

Identifiers

PMID33087319
PMCPMC7770264

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.