Evidence map›Paper›PMID 33087261›Full record

ReviewDNA repair2020

DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential.

Yaping Huang, Guo-Min Li

Open access · greenAbstract readReview
In one paragraph

Review in DNA repair, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Roles of NRF2 in DNA damage repair.Cellular oncology (Dordrecht, Netherlands) · 2023
    Review
  6. Article
  7. Review
  8. Mutperiod: Analysis of periodic mutation rates in nucleosomes.Computational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yaping HuangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.
Guo-Min LiDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA. Electronic address: guo-min.li@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

Novel Mechanism Ensuring Replication FidelityR01GM112702 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LI, GUO-MIN · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM112702
6 · The paper itself

Abstract

DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and precisely regulated in the context of chromatin; strikingly, tumors defective in MMR are highly responsive to immune checkpoint blockade therapy. As a tribute to Dr. Samuel Wilson for his many scientific contributions to the field of DNA repair and his leadership as Editor-in-Chief of the journal DNA Repair, we summarize recent developments in research on MMR at the chromatin level, its implications for tumorigenesis, and its therapeutic potential.

Indexed as

DNA Mismatch RepairCarcinogenesisChromatinDNA DamageHumansNeoplasmsChromatinCancer therapyChromatin structureMimsatch repairReplication fork

Identifiers

PMID33087261
PMCPMC7583346
OpenAlexW3094089465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.