Evidence map›Paper›PMID 33087170›Full record

ArticleTrials2020

Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia.

Katie Beck-Felts, Marianne Goodman, Luz H Ospina, Melanie Wall, Joseph McEvoy, Lars F Jarskog, Jacob S Ballon, Matthew N Bartels, Richard Buchsbaum, Richard P Sloan and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03270098 (Improving Cognition Via Exercise in Schizophrenia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03270098 nacompletednot on this map

Improving Cognition Via Exercise in Schizophrenia

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2018 to 2023Enrolled104ConditionsSchizophrenia and Related DisordersArmsAerobic Exercise, Stretching and Toning Exercise
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Katie Beck-FeltsDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA.
Marianne GoodmanMIRECC, James J. Peters VA Medical Center, Bronx, NY, USA.
Luz H OspinaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA.
Melanie WallDepartment of Psychiatry, Columbia University, New York, NY, USA.
Joseph McEvoyDepartment of Psychiatry and Health Behavior, Georgia Regents University, Augusta, GA, USA.
Lars F JarskogDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Jacob S BallonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Matthew N BartelsDepartment of Rehabilitation Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Richard BuchsbaumDepartment of Psychiatry, Columbia University, New York, NY, USA.
Richard P SloanDepartment of Psychiatry, Columbia University, New York, NY, USA.
T Scott StroupDepartment of Psychiatry, Columbia University, New York, NY, USA.
David KimhyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA. david.kimhy@mssm.edu.ORCID http://orcid.org/0000-0001-7735-9378
Columbia University · USIcahn School of Medicine at Mount Sinai · USJames J. Peters VA Medical Center · USAlbert Einstein College of Medicine · USAugusta University · USStanford University · USUniversity of North Carolina at Chapel Hill · US

Funding

SUicide Reduction In Schizophrenia via Exercise (SUnRISE)R01MH110623 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KIMHY, DAVID, STROUP, THOMAS SCOTT · 2017 to 2020
$6.4M
NIMH NIH HHS R01 MH110623NIMH NIH HHS R01MH110623
6 · The paper itself

Abstract

backgroundSuicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5-10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction benefits, and thus, there remains an urgent need to explore novel interventions that will ameliorate this risk. Aerobic exercise (AE) has been shown to improve a number of predictors of suicide risk (e.g., depressed mood, sleeping difficulties). As individuals with SZ display a highly sedentary lifestyle, AE may reduce suicide risk.

methodsEmploying a multi-site, single-blind, randomized clinical trial design, we will examine the impact of AE on risk for suicide and related variables in individuals with SZ. Participants will be randomized to one of two 12-week exercise interventions: AE or a stretching and toning (ST) control intervention. Primary outcome measures will include suicide risk (Columbia Suicide Severity Rating Scale, C-SSRS) and aerobic fitness (VO DISCUSSION: It is hypothesized that AE will reduce suicide risk among individuals with SZ. This study may offer support for a more efficacious treatment method for this population in addition to the pre-existing pharmacological and psychotherapeutic treatment regimens.

trial registrationClinicaltrials.gov, NCT03270098 . Registered on September 1, 2017.

Indexed as

SchizophreniaSuicide PreventionExerciseExercise TherapyHumansRandomized Controlled Trials as TopicRisk Reduction BehaviorSingle-Blind MethodTreatment OutcomeAerobic fitnessExerciseSchizophreniaSuicideVO2max

Identifiers

PMID33087170
PMCPMC7579916
OpenAlexW3093649044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.