Evidence map›Paper›PMID 33087137›Full record

ReviewJournal of neuroengineering and rehabilitation2020

These legs were made for propulsion: advancing the diagnosis and treatment of post-stroke propulsion deficits.

Louis N Awad, Michael D Lewek, Trisha M Kesar, Jason R Franz, Mark G Bowden

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07218094 (Neuromechanical Mechanisms of Exosuit-assisted Gait Rehabilitation After Stroke), which is not on this map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07218094 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Neuromechanical Mechanisms of Exosuit-assisted Gait Rehabilitation After Stroke

TypeinterventionalSponsorBoston University Charles River CampusRan2025 to 2027Enrolled22ConditionsStrokeArmsWalking with robotic ankle assistance
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 103 citations in OpenAlex.

  1. Effect of ultrasound-guided acupotomy combined with acupuncture on limb dysfunction in patients with cerebral stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  14. Gait Adaptation to Asymmetric Foot-Ground Compliance Applied by Robotic Footwear.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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  15. Effects of Belt Accelerations During Push-Off on Propulsion Mechanics in Individuals Post-Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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  18. Walking speed can be modulated on an adaptive split-belt treadmill.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Louis N AwadCollege of Health and Rehabilitation Sciences: Sargent College, Boston University, Boston, MA, USA. louawad@bu.edu.ORCID 0000-0002-0159-8011
Michael D LewekDivision of Physical Therapy, Department of Allied Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Trisha M KesarDivision of Physical Therapy, Emory University, Atlanta, GA, USA.
Jason R FranzJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, USA.
Mark G BowdenDivision of Physical Therapy, Medical University of South Carolina, Charleston, SC, USA.
University of North Carolina at Chapel Hill · USBoston University · USEmory University · USMedical University of South Carolina · US

Funding

Biomechanical and neural mechanisms of post-stroke gait trainingR01HD095975 · NICHD · EMORY UNIVERSITY · PI KESAR, TRISHA · 2019 to 2024
$2.9M
SCH: Multimodal,Task-Aware Movement Assessment and Control: Clinic to HomeR01AG067394 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI AWAD, LOUIS N, TRON, ROBERTO · 2019 to 2022
$1.2M
Cortical and spinal correlates of stroke gait rehabilitationK01HD079584 · NICHD · EMORY UNIVERSITY · PI KESAR, TRISHA · 2014 to 2018
$632k
NIA NIH HHS R01 AG067394NICHD NIH HHS K01 HD079584NICHD NIH HHS R01 HD095975
6 · The paper itself

Abstract

Advances in medical diagnosis and treatment have facilitated the emergence of precision medicine. In contrast, locomotor rehabilitation for individuals with acquired neuromotor injuries remains limited by the dearth of (i) diagnostic approaches that can identify the specific neuromuscular, biomechanical, and clinical deficits underlying impaired locomotion and (ii) evidence-based, targeted treatments. In particular, impaired propulsion by the paretic limb is a major contributor to walking-related disability after stroke; however, few interventions have been able to target deficits in propulsion effectively and in a manner that reduces walking disability. Indeed, the weakness and impaired control that is characteristic of post-stroke hemiparesis leads to heterogeneous deficits that impair paretic propulsion and contribute to a slow, metabolically-expensive, and unstable gait. Current rehabilitation paradigms emphasize the rapid attainment of walking independence, not the restoration of normal propulsion function. Although walking independence is an important goal for stroke survivors, independence achieved via compensatory strategies may prevent the recovery of propulsion needed for the fast, economical, and stable gait that is characteristic of healthy bipedal locomotion. We posit that post-stroke rehabilitation should aim to promote independent walking, in part, through the acquisition of enhanced propulsion. In this expert review, we present the biomechanical and functional consequences of post-stroke propulsion deficits, review advances in our understanding of the nature of post-stroke propulsion impairment, and discuss emerging diagnostic and treatment approaches that have the potential to facilitate new rehabilitation paradigms targeting propulsion restoration.

Indexed as

Stroke RehabilitationBiomechanical PhenomenaFemaleGait Disorders, NeurologicHumansLegLocomotionMaleMiddle AgedParesisStrokeWalkingDiagnosisInterventionLocomotionPropulsionRehabilitationRoboticsSensorsWalking

Identifiers

PMID33087137
PMCPMC7579929
OpenAlexW3094148904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.