Evidence map›Paper›PMID 33087092›Full record

ArticleBMC pediatrics2020

Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children.

Thomas Waterfield, Julie-Ann Maney, Mark D Lyttle, James P McKenna, Damian Roland, Michael Corr, Bethany Patenall, Michael D Shields, Kerry Woolfall, Derek Fairley and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03378258 (Petechiae In Children), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03378258 completednot on this map

Petechiae In Children (PIC) Study

TypeobservationalSponsorBelfast Health and Social Care TrustRan2017 to 2019Enrolled1,329ConditionsMeningitis, Meningococcal, Meningococcal Sepsis, Meningococcal Disease, Meningococcal Infections
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Assessing Biomarkers in Viral Infection.Advances in experimental medicine and biology · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Thomas WaterfieldEmergency Department, Royal Belfast Hospital for Sick Children, Belfast, UK. twaterfield01@qub.ac.uk.
Julie-Ann ManeyEmergency Department, Royal Belfast Hospital for Sick Children, Belfast, UK.
Mark D LyttleEmergency Department, Bristol Royal Hospital for Children, Bristol, UK.
James P McKennaDepartment of Microbiology, Belfast Health and Social Care Trust, Belfast, UK.
Damian RolandSAPPHIRE Group, Health Sciences, Leicester University, Leicester, UK.
Michael CorrBelfast Health and Social Care Trust, Belfast, UK.
Bethany PatenallDepartment of Chemistry, University of Bath, Bath, UK.
Michael D ShieldsCentre for Experimental Medicine, Wellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, UK.
Kerry WoolfallInstitute of Population Health and Society, University of Liverpool, Liverpool, UK.
Derek FairleyCentre for Experimental Medicine, Wellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, UK.
Paediatric Emergency Research in the UK and Ireland (PERUKI)
Belfast Health and Social Care Trust · GBQueen's University Belfast · GBRoyal Belfast Hospital for Sick Children · GBBristol Royal Hospital for Children · GBLeicester Royal Infirmary · GBUniversity of Bath · GBUniversity of Liverpool · GB

Funding

Public Health Agency EAT/5313/16Royal College of Emergency Medicine N/A
6 · The paper itself

Abstract

backgroundThe National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of this study was to compare the diagnostic test accuracy of C-reactive protein (CRP) and PCT for the diagnosis of SBI in children.

methodsData was collected prospectively from four UK emergency departments (ED) between November 2017 and June 2019. Consecutive children under 18 years of age with fever and features of possible sepsis and/or meningitis were eligible for inclusion. The index tests were PCT and CRP and the reference standard was the confirmation of SBI.

results213 children were included in the final analysis. 116 participants (54.5%) were male, and the median age was 2 years, 9 months. Parenteral antibiotics were given to 100 (46.9%), three (1.4%) were admitted to a paediatric intensive care unit and there were no deaths. There were ten (4.7%) confirmed SBI. The area under the curve for PCT and CRP for the detection of SBI was identical at 0.70.

conclusionsThere was no difference in the performance of PCT and CRP for the recognition of SBI in this cohort.

trial registrationRegistered at https://www.clinicaltrials.gov (trial registration: NCT03378258 ) on the 19th of December 2017.

Indexed as

Bacterial InfectionsProcalcitoninAdolescentBiomarkersChildChild, PreschoolC-Reactive ProteinDiagnostic Tests, RoutineFemaleHumansMalePoint-of-Care SystemsProspective StudiesBiomarkersC-Reactive ProteinProcalcitoninbacterial infectionbiomarkersinfectionpaediatricsProcalcitonin

Identifiers

PMID33087092
PMCPMC7576699
OpenAlexW3094586660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.