Evidence map›Paper›PMID 33086948›Full record

ArticleTissue engineering. Part C, Methods2020

Role of Curcuminoids and Tricalcium Phosphate Ceramic in Rat Spinal Fusion.

Daniel A Ryan, Jiongjia Cheng, Koichi Masuda, John R Cashman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part C, Methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daniel A RyanHuman BioMolecular Research Institute, San Diego, California, USA.
Jiongjia ChengHuman BioMolecular Research Institute, San Diego, California, USA.
Koichi MasudaDepartment of Orthopedic Surgery, University of California, San Diego, San Diego, California, USA.
John R CashmanHuman BioMolecular Research Institute, San Diego, California, USA.
Human BioMolecular Research Institute · USUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite considerable research effort, there is a significant need for safe agents that stimulate bone formation. Treatment of large or complex bone defects remains a challenge. Implantation of small molecule-induced human bone marrow-derived mesenchymal stromal cells (hBMSCs) on an appropriate tricalcium phosphate (TCP) scaffold offers a robust system for noninvasive therapy for spinal fusion. To show the efficacy of this approach, we identified a small molecule curcuminoid that when combined with TCP ceramic in the presence of hBMSCs selectively induced growth of bone cells: after 8- or 25-day incubations, alkaline phosphatase was elevated. Treatment of hBMSCs with curcuminoid 1 and TCP ceramic increased osteogenic target gene expression (i.e.,

Indexed as

Spinal FusionAlkaline PhosphataseAnimalsCalciumCalcium PhosphatesCell DifferentiationCell SurvivalCeramicsCollagenDiarylheptanoidsGene Expression RegulationHumansImplants, ExperimentalMaleMesenchymal Stem CellsMineralsAlkaline PhosphataseCalciumCalcium PhosphatesCollagenDiarylheptanoidsMineralstricalcium phosphateWnt Proteinsbone growthbone marrow-derived mesenchymal stem cellscurcuminstricalcium phosphate ceramic

Identifiers

PMID33086948
PMCPMC7699001
OpenAlexW3094626977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.