Evidence map›Paper›PMID 33086749›Full record

Trial reportToxins2020

Safety and Stability of Pulmonary Function in Patients with Decreased Respiratory Function Treated for Spasticity with OnabotulinumtoxinA.

Ziyad Ayyoub, Allison Brashear, Marta Banach, Robert Schoene, William Stringer, Terry Boodhoo, Irina Yushmanova, Rozalina Dimitrova, Mitchell F Brin

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Ziyad AyyoubRancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA.
Allison BrashearDepartment of Neurology, University of California, Sacramento, CA 95817, USA.
Marta BanachDepartment of Neurology, Jagiellonian University, 31-007 Krakow, Poland.
Robert SchoeneSound Physicians, San Francisco, CA 95116, USA.
William StringerLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.ORCID 0000-0003-2756-6728
Terry BoodhooAllergan plc, an AbbVie Company, Irvine, CA 92612, USA.
Irina YushmanovaAllergan plc, an AbbVie Company, Irvine, CA 92612, USA.
Rozalina DimitrovaAllergan plc, an AbbVie Company, Irvine, CA 92612, USA.
Mitchell F BrinAllergan plc, an AbbVie Company, Irvine, CA 92612, USA.ORCID 0000-0002-1989-6076
AbbVie (United States) · USCalifornia State University, Sacramento · USJagiellonian University · PLUCLA Medical Center · USUniversity of California, Irvine · USUniversity of California, Los Angeles · US

Funding

ALLERGAN, an ABBVIE company n/a
6 · The paper itself

Abstract

Two randomized, placebo-controlled studies evaluated the pulmonary function safety of onabotulinumtoxinA (onabotA) for treatment of upper and/or lower limb spasticity. Patients with stable baseline respiratory status received one or two treatments with placebo, 240 U, or 360 U of onabotA. Pulmonary function tests, adverse events, and efficacy were measured at least every 6 weeks for 18 weeks (Study 1) or 30 weeks (Study 2). Study 1 enrolled 109 patients (

Indexed as

Acetylcholine Release InhibitorsBotulinum Toxins, Type ADouble-Blind MethodEuropeFemaleForced Expiratory VolumeHumansLower ExtremityLungLung DiseasesMaleMiddle AgedMuscle SpasticityProspective StudiesTime FactorsTreatment OutcomeAcetylcholine Release InhibitorsBotulinum Toxins, Type Abotulinum toxin type Aforced expiratory volumeforced vital capacityonabotulinumtoxinApulmonary function testingrespiratory functionspasticity

Identifiers

PMID33086749
PMCPMC7589715
OpenAlexW3094217367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.