Evidence map›Paper›PMID 33086734›Full record

ArticleSensors (Basel, Switzerland)2020

Gait Characteristics Harvested During a Smartphone-Based Self-Administered 2-Minute Walk Test in People with Multiple Sclerosis: Test-Retest Reliability and Minimum Detectable Change.

Alan K Bourke, Alf Scotland, Florian Lipsmeier, Christian Gossens, Michael Lindemann

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A smartphone sensor-based digital outcome assessment of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Trial
  4. Article
  5. Evaluation of the Wisconsin Gait Scale in Patients With Multiple Sclerosis and Spastic Hemiplegia.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  6. Article
  7. Sensors in Multiple Sclerosis.Current neurology and neuroscience reports · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. From progression to progress: The future of multiple sclerosis.Journal of central nervous system disease · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Longitudinal Trend Monitoring of Multiple Sclerosis Ambulation Using Smartphones.IEEE open journal of engineering in medicine and biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alan K BourkeRoche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.ORCID 0000-0002-7111-422X
Alf ScotlandInovigate, Aeschenvorstadt 55, 4051 Basel, Switzerland.
Florian LipsmeierRoche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Christian GossensRoche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Michael LindemannRoche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Roche (Switzerland) · CH

Funding

This research was funded by F Hoffmann-La Roche Ltd, Basel, Switzerland. *
6 · The paper itself

Abstract

The measurement of gait characteristics during a self-administered 2-minute walk test (2MWT), in persons with multiple sclerosis (PwMS), using a single body-worn device, has the potential to provide high-density longitudinal information on disease progression, beyond what is currently measured in the clinician-administered 2MWT. The purpose of this study is to determine the test-retest reliability, standard error of measurement (SEM) and minimum detectable change (MDC) of features calculated on gait characteristics, harvested during a self-administered 2MWT in a home environment, in 51 PwMS and 11 healthy control (HC) subjects over 24 weeks, using a single waist-worn inertial sensor-based smartphone. Excellent, or good to excellent test-retest reliability were observed in 58 of the 92 temporal, spatial and spatiotemporal gait features in PwMS. However, these were less reliable for HCs. Low SEM% and MDC% values were observed for most of the distribution measures for all gait characteristics for PwMS and HCs. This study demonstrates the inter-session test-retest reliability and provides an indication of clinically important change estimates, for interpreting the outcomes of gait characteristics measured using a body-worn smartphone, during a self-administered 2MWT. This system thus provides a reliable measure of gait characteristics in PwMS, supporting its application for the longitudinal assessment of gait deficits in this population.

Indexed as

Multiple SclerosisSmartphoneWalk TestFemaleGaitHumansReproducibility of ResultsWalking2-minute walk testgaitMDCmultiple sclerosisSEMsmartphonetest-retest reliabilitywearable sensors

Identifiers

PMID33086734
PMCPMC7589972
OpenAlexW3093426924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.