Evidence map›Paper›PMID 33086673›Full record

ArticlePharmaceutics2020

Evaluation of CpG-ODN-Adjuvanted

Hae-Ji Kang, Ki-Back Chu, Min-Ju Kim, Hyunwoo Park, Hui Jin, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Advances inVaccines · 2021
    Review
  11. Mucosal Administration of Recombinant Baculovirus DisplayingFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hae-Ji KangDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Ki-Back ChuDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Min-Ju KimDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Hyunwoo ParkHealth Park Co., Ltd., Seoul 06627, Korea.
Hui JinHealth Park Co., Ltd., Seoul 06627, Korea.
Su-Hwa LeeDepartment of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
Eun-Kyung MoonDepartment of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
Fu-Shi QuanDepartment of Medical Zoology, Kyung Hee University School of Medicine, Seoul 02447, Korea.
Kyung Hee University · KRKyung Hee University Medical Center · KR

Funding

Ministry of Health and Welfare HI15C2928National Research Foundation of Korea 2018R1A2B6003535National Research Foundation of Korea 2018R1A6A1A03025124
6 · The paper itself

Abstract

Successful vaccines against specific pathogens often require multiple immunizations and adjuvant usage. Yet, assessing the protective efficacy of different immunization regimens with adjuvanted Toxoplasma gondii vaccines remains elusive. In this study, we investigated the vaccine efficacy induced by CpG-ODN-adjuvanted T. gondii virus-like particles (VLPs) after challenge infection with T. gondii (ME49) in mice (BALB/c) upon one, two, and three immunizations. Immunization with adjuvanted T. gondii VLPs induced higher levels of T. gondii-specific IgG and/or IgA antibody responses, germinal center (GC) B cells, total B cells, and CD4

Indexed as

CpG-ODNToxoplasma gondiivaccinevirus-like particle

Identifiers

PMID33086673
PMCPMC7588908
OpenAlexW3092888956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.