ArticleNutrients2020
Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.Frontiers in neuroscience · 2026Pooled it
- Pooled it
- High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Prenatal iron supplementation adjusted to maternal iron stores reduces behavioural problems in 4-year-old children.Maternal & child nutrition · 2024Trial
- Vitamin D and Child Neurodevelopment-A Post Hoc Analysis.Nutrients · 2023Trial
- [Vitamin D level in umbilical cord blood of late preterm infants and the effect of vitamin DZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Trial
- Prenatal sunlight in the second trimester predicts timing of menarche in Polish women born between 1985 and 1991.International journal of biometeorology · 2026Article
- Breastfeeding status, micronutrient biomarkers, thyroid function, and Bayley-III developmental outcomes in Taiwanese toddlers.International breastfeeding journal · 2026Article
- Review
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- Prenatal vitamin D status and long-term neurocognitive outcomes: building on an emerging evidence base.Pediatric research · 2026Article
- Vitamin D status during pregnancy and child neurocognitive functioning at 4 Years.Pediatric research · 2026Article
- The KLOTHO Birth Cohort: Maternal and Neonatal Vitamin D Status and Neurodevelopmental Outcomes at 10 Years.Nutrients · 2025Article
- Maternal Micronutrient Status During Pregnancy and Its Neurodevelopmental Implications for Infants in South Asia: Protocol for a Scoping Review.JMIR research protocols · 2025Article
- Gestational vitamin D concentration and child cognitive development: a longitudinal cohort study in the Environmental influences on Child Health Outcomes Program.The American journal of clinical nutrition · 2025Article
- Sleep and circadian disturbances in children with neurodevelopmental disorders.Nature reviews. Neurology · 2025Review
- The metabolic role of vitamin D in children's neurodevelopment: a network study.Scientific reports · 2024Article
- Unveiling the Novel Impact of Vitamin D Injections at Birth on the Prognosis of Newborns: A Double-blind Study.Oman medical journal · 2024Article
- Association between Prenatal Dietary Toxicants and Infant Neurodevelopment: The Role of Fish.Toxics · 2024Article
- The Maternal Omega-3 Long-Chain Polyunsaturated Fatty Acid Concentration in Early Pregnancy and Infant Neurodevelopment: The ECLIPSES Study.Nutrients · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother-infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.