ArticleMolecules (Basel, Switzerland)2020
Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 60 citations in OpenAlex.
- Design and characterisation of a film-forming emulsion combining enhanced skin permeability with prolonged drug delivery.Biomaterials and biosystems · 2026Article
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- Recent Progress in Photocatalytic Applications of Electrospun Nanofibers: A Review.Molecules (Basel, Switzerland) · 2024Review
- Prolonged retention of luliconazole nanofibers for topical mycotic condition: development, in vitro characterization and antifungal activity against Candida albicans.Journal of materials science. Materials in medicine · 2024Article
- Tissue-Mimicking Material Fabrication and Properties for Multiparametric Ultrasound Phantoms: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Drug Delivery Systems of Betulin and Its Derivatives: An Overview.Biomedicines · 2024Review
- PVA-Based Electrospun Materials-A Promising Route to Designing Nanofiber Mats with Desired Morphological Shape-A Review.International journal of molecular sciences · 2024Review
- State-of-the-Art Review of Advanced Electrospun Nanofiber Composites for Enhanced Wound Healing.AAPS PharmSciTech · 2023Review
- Recent Advances in Electrospun Nanofiber-Based Strategies for Diabetic Wound Healing Application.Pharmaceutics · 2023Review
- The Effect of Gamma-Ray Irradiation on the Physical, Mechanical, and Morphological Characteristics of PVA-Collagen-Chitosan as a Guided Tissue Regeneration (GTR) Membrane Material.European journal of dentistry · 2023Article
- Formulation and Characterization of Electrospun Nanofibers for Melatonin Ocular Delivery.Pharmaceutics · 2023Article
- Characterizing optimum electrospinning conditions for graft urethanized Poly(Vinyl Alcohol)(U-PVA).Heliyon · 2022Article
- Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles.International journal of molecular sciences · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects including enhanced wound healing. Apart from an already authorized oleogel, electrospun nanofiber mats containing these triterpenes in a polyvinyl alcohol (PVA) matrix appear to be an advantageous application form. The effects of PVA molecular weight and concentration on the fiber morphology have been investigated. Three different molecular weights of PVA ranging from 67 to 186 kDa were used. The concentration of PVA was varied from 5 to 20 wt%. Polymer solutions were blended with colloidal dispersions of birch bark extract at a weight ratio of 60:40 (wt.%). The estimated viscosity of polymer solutions was directly linked to their concentration and molecular weight. In addition, both pure and blended solutions showed viscoelastic properties with a dominant viscous response in the bulk. Fiber morphology was confirmed using scanning electron microscopy (SEM). Both polymer concentration and molecular weight were found to be significant factors affecting the diameter of the fibers. Fiber diameter increased with a higher molecular weight and polymer concentration as more uniform fibers were obtained using PVA of higher molecular weight (146-186 kDa). In vitro drug release and ex vivo permeation studies indicated a faster drug release of betulin from electrospun scaffolds with lower PVA molecular weight. Our research suggests that the fabricated TE-loaded PVA electrospun dressings represent potential delivery systems of TE for wound care applications.
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