ArticleInternational journal of environmental research and public health2020
The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
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- A health resort-based intervention reduces insomnia with minimal changes in quality of life in COVID-19 survivors and non-COVID-19 controls.Frontiers in public health · 2026Article
- Effects of Lifestyle, Diet, and Body Composition on Free Testosterone and Cortisol Levels in Young Men.Nutrients · 2025Article
- Influence of the HPA Axis on Anxiety-Related Processes: An RDoC Overview Considering Their Neural Correlates.Current psychiatry reports · 2025Review
- Combined effect of cognitive dysfunction and sleep disturbance on mortality risk: NHANES 2011-2014.Annals of general psychiatry · 2025Article
- The relationship between trait anxiety and sleep quality in college students: an exploratory analysis of physical activity as a moderator.Frontiers in psychiatry · 2025Article
- Anxiety and Depression and Sleep Problems Among Patients with Fetal Alcohol Spectrum Disorders.Children (Basel, Switzerland) · 2024Article
- Relationship between social anxiety and sleep quality in depressed adolescents: the mediating role of internet addiction.Frontiers in psychiatry · 2024Article
- Poor subjective sleep reported by people living with HIV is associated with impaired working memory.NeuroImmune pharmacology and therapeutics · 2023Article
- A nationwide study on pain manifestations and sleep problems in community-dwelling older adults: findings from ELSI-Brazil.European geriatric medicine · 2023Article
- The Correlation Between Night Shift Work Schedules, Sleep Quality, and Depression Symptoms.Neuropsychiatric disease and treatment · 2023Article
- The Associations of Psychologic and Physiologic Manifestations of Parental Stress in Critical Congenital Heart Disease.Biological research for nursing · 2022Article
- Acute Sleep Deprivation-Induced Anxiety and Disruption of Hypothalamic Cell Survival and Plasticity: A Mechanistic Study of Protection by Butanol Extract of Tinospora cordifolia.Neurochemical research · 2022Article
- Prenatal earthquake stress exposure in different gestational trimesters is associated with methylation changes in the glucocorticoid receptor gene (NR3C1) and long-term working memory in adulthood.Translational psychiatry · 2022Article
- Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep plays a crucial role in cognitive processes. Sleep and wake memory consolidation seem to be regulated by glucocorticoids, pointing out the potential role of the hypothalamic-pituitary-adrenal (HPA) axis in the relationship between sleep quality and cognitive abilities. Trait anxiety is another factor that is likely to moderate the relationship between sleep and cognition, because poorer sleep quality and subtle HPA axis abnormalities have been reported in people with high trait anxiety. The current study aimed to explore whether HPA axis activity or trait anxiety moderate the relationship between sleep quality and cognitive abilities in healthy individuals. We studied 203 healthy individuals. We measured verbal and visual memory, working memory, processing speed, attention and executive function. Sleep quality was assessed with the Pittsburgh Sleep Quality Index. Trait anxiety was assessed with the State-Trait Anxiety Inventory. HPA axis measures included the cortisol awakening response (CAR), diurnal cortisol slope and cortisol levels during the day. Multiple linear regression analyses explored the relationship between sleep quality and cognition and tested potential moderating effects by HPA axis measures and trait anxiety. Poor sleep quality was associated with poorer performance in memory, processing speed and executive function tasks. In people with poorer sleep quality, a blunted CAR was associated with poorer verbal and visual memory and executive functions, and higher cortisol levels during the day were associated with poorer processing speed. Trait anxiety was a moderator of visual memory and executive functioning. These results suggest that subtle abnormalities in the HPA axis and higher trait anxiety contribute to the relationship between lower sleep quality and poorer cognitive functioning in healthy individuals.
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