ArticleNutrients2020
Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy.
Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Ex Vivo Immune Response of Casein-Sensitized Lymphocytes to Bovine Milk Protein Composite Genotypes: Beyond the β-Casein A1/A2 Paradigm.Nutrients · 2026Article
- How to Employ Trained Immunity and Trained Immunity-Based Vaccines to Inhibit Allergic Inflammation.Vaccines · 2026Review
- Review
- From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases.Epigenomics · 2025Review
- Epigenetic Alterations in PAH-Induced Childhood Asthma: An Intervention Using Sulforaphane.Toxics · 2025Article
- Chromatin Immunoprecipitation Sequencing (ChIP-Seq) Assay in Food Allergy Research.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Epigenomic and epigenetic investigations of food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Review
- Pathogenesis of allergic diseases and implications for therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- Immunologic, genetic, and ecological interplay of factors involved in allergic diseases.Frontiers in allergy · 2023Review
- Short-Chain Fatty Acids Augment Differentiation and Function of Human Induced Regulatory T Cells.International journal of molecular sciences · 2022Article
- Immunomodulatory Role of BLG-Derived Peptides Based on Simulated Gastrointestinal Digestion and DC-T Cell from Mice Allergic to Cow's Milk.Foods (Basel, Switzerland) · 2022Article
- Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy.Nutrients · 2022Article
- Preventive Effects of a Human Hematopoietic Mesenchymal Stem Cell (hHMSC) Therapy in Ovalbumin-Induced Food Allergy.Biomedicines · 2022Article
- MALAT1 Induces Food Allergy by Promoting Release of IL-6 from Dendritic Cells and Suppressing the Immunomodulatory Function of Tregs.Journal of asthma and allergy · 2022Article
- Epigenetics in Food Allergy and Immunomodulation.Nutrients · 2021Review
- The Interplay of Nutriepigenomics, Personalized Nutrition and Clinical Practice in Managing Food Allergy.Life (Basel, Switzerland) · 2021Review
- Article
- Anti-Allergic Diarrhea Effect of Diosgenin Occurs via Improving Gut Dysbiosis in a Murine Model of Food Allergy.Molecules (Basel, Switzerland) · 2021Article
- Non-IgE- or Mixed IgE/Non-IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis.Nutrients · 2021Review
- Biomarkers in oral immunotherapy.Journal of Zhejiang University. Science. BReview
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin E (IgE)-mediated allergy against cow's milk protein fractions such as whey is one of the most common food-related allergic disorders of early childhood. Histone acetylation is an important epigenetic mechanism, shown to be involved in the pathogenesis of allergies. However, its role in food allergy remains unknown. IgE-mediated cow's milk allergy was successfully induced in a mouse model, as demonstrated by acute allergic symptoms, whey-specific IgE in serum, and the activation of mast cells upon a challenge with whey protein. The elicited allergic response coincided with reduced percentages of regulatory T (Treg) and T helper 17 (Th17) cells, matching decreased levels of H3 and/or H4 histone acetylation at pivotal Treg and Th17 loci, an epigenetic status favoring lower gene expression. In addition, histone acetylation levels at the crucial T helper 1 (Th1) loci were decreased, most probably preceding the expected reduction in Th1 cells after inducing an allergic response. No changes were observed for T helper 2 cells. However, increased histone acetylation levels, promoting gene expression, were observed at the signal transducer and activator of transcription 6 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.