ReviewInternational journal of molecular sciences2020
Molecular Aspects of Thyroid Calcification.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Sociodemographic and clinical predictors of malignancy in thyroid nodules: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- The impact of psammoma bodies on long-term prognosis in papillary thyroid carcinoma.Endocrine · 2026Article
- Development of a predictive model using key ultrasound characteristics to distinguish follicular thyroid neoplasms from nodular goiter.Pakistan journal of medical sciences · 2026Article
- Malignancy rate of cervical lymph nodes based on concordance of ultrasound and computed tomography imaging features in patients with thyroid cancer.Ultrasonography (Seoul, Korea) · 2026Article
- Effects of thyroiditis on the diagnostic performance of fine-needle aspiration cytology- clinico-radiologico-cytological analysis of risk factors for discordance.BMC endocrine disorders · 2026Article
- A clinically practical machine learning nomogram for preoperative CLNM prediction in PTMC: tumor-capsule distance and D2-40 evidence.Frontiers in oncology · 2026Article
- Nomogram integrating BRAF V600E, serum biomarkers, and ultrasound features for malignancy risk stratification in C-TIRADS category 3 and 4 thyroid nodules.Frontiers in medicine · 2026Article
- A "calcification"-enhanced deep learning approach for precise differentiation of thyroid nodules.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Diagnostic value of a dynamic artificial intelligence-based, ultrasound-assisted diagnostic system in differentiating between benign and malignant thyroid nodules with a diameter greater than 2 cm.Quantitative imaging in medicine and surgery · 2025Article
- Prospective Validation of an Ultrasound Capsule-Based Model for Predicting Follicular Thyroid Carcinoma Without High-Risk Features.Cancer medicine · 2025Article
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- The value of ultrasonographic scoring method and nomogram in assessing cervical lymph node metastasis of papillary thyroid carcinoma.Thyroid research · 2025Article
- Predictive Factors for Malignancy in Atypiai of Undetermined Significance (AUS) Thyroid Nodules: A Comprehensive Retrospective Analysis.Current oncology (Toronto, Ont.) · 2025Article
- Predicting central lymph node metastasis in papillary thyroid carcinoma combined with Hashimoto's thyroiditis: a preoperative study.BMC cancer · 2025Article
- Psammoma bodies in thyroid: are they always indicative of malignancy? A multi-institutional study.Virchows Archiv : an international journal of pathology · 2024Article
- Factors Affecting Cell Viability during the Enzymatic Dissociation of Human Endocrine Tumor Tissues.Biology · 2024Article
- A nomogram for risk stratification of central cervical lymph node metastasis in patients with papillary thyroid carcinoma.Quantitative imaging in medicine and surgery · 2024Article
- Personalized Management of Malignant and Non-Malignant Ectopic Mediastinal Thyroid: A Proposed 10-Item Algorithm Approach.Cancers · 2024Review
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In thyroid cancer, calcification is mainly present in classical papillary thyroid carcinoma (PTC) and in medullary thyroid carcinoma (MTC), despite being described in benign lesions and in other subtypes of thyroid carcinomas. Thyroid calcifications are classified according to their diameter and location. At ultrasonography, microcalcifications appear as hyperechoic spots ≤ 1 mm in diameter and can be named as stromal calcification, bone formation, or psammoma bodies (PBs), whereas calcifications > 1 mm are macrocalcifications. The mechanism of their formation is still poorly understood. Microcalcifications are generally accepted as a reliable indicator of malignancy as they mostly represent PBs. In order to progress in terms of the understanding of the mechanisms behind calcification occurring in thyroid tumors in general, and in PTC in particular, we decided to use histopathology as the basis of the possible cellular and molecular mechanisms of calcification formation in thyroid cancer. We explored the involvement of molecules such as runt-related transcription factor-2 (Runx-2), osteonectin/secreted protein acidic and rich in cysteine (SPARC), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteopontin (OPN) in the formation of calcification. The present review offers a novel insight into the mechanisms underlying the development of calcification in thyroid cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.