ReviewMolecules (Basel, Switzerland)2020
Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine.Tissue engineering and regenerative medicine · 2023Pooled it
- Natural Bioactive Compounds in Dental Materials: Balancing Biological Activity and Functional Properties.Pharmaceutics · 2026Review
- Advances in biomimetic mineralized biomaterials for bone tissue engineering.Regenerative biomaterials · 2026Review
- In situ Synthesis of Amorphous Fluorinated Calcium Phosphate Nanoparticles via a Dual-Component Hydrogel for Biomimetic Tooth Remineralization.International journal of nanomedicine · 2026Article
- Core-shell silica and fluorogenic hyaluronan nanomaterials in magnesium hydroxyapatite scaffolds for bone regeneration.Scientific reports · 2025Article
- Hydrogel-Based Scaffolds: Advancing Bone Regeneration Through Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- Advances in macro-bioactive materials enhancing dentin bonding.Discover nano · 2025Review
- Hybrid Hydroxyapatite-Metal Complex Materials Derived from Amino Acids and Nucleobases.Molecules (Basel, Switzerland) · 2024Review
- Polysaccharide-Based Composite Systems in Bone Tissue Engineering: A Review.Materials (Basel, Switzerland) · 2024Review
- Towards Complex Tissues Replication: Multilayer Scaffold Integrating Biomimetic Nanohydroxyapatite/Chitosan Composites.Bioengineering (Basel, Switzerland) · 2024Article
- Effect of Chitosan Degradation Products, Glucosamine and Chitosan Oligosaccharide, on Osteoclastic Differentiation.Biotech (Basel (Switzerland)) · 2024Article
- Matrix Metalloproteinases in the Periodontium-Vital in Tissue Turnover and Unfortunate in Periodontitis.International journal of molecular sciences · 2024Review
- Chitosan nanoparticle applications in dentistry: a sustainable biopolymer.Frontiers in chemistry · 2024Review
- The role of bacterial infections in rheumatoid arthritis development and novel therapeutic interventions: Focus on oral infections.Journal of clinical laboratory analysis · 2023Review
- Research Progress of the Ion Activity Coefficient of Polyelectrolytes: A Review.Molecules (Basel, Switzerland) · 2023Review
- The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering.Pharmaceutics · 2023Review
- Chitosan-Based Scaffolds for Facilitated Endogenous Bone Re-Generation.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Special Issue: Biomimetic Organic-Inorganic Composites.Materials (Basel, Switzerland) · 2022Article
- Preparation and Characterization of Mg-Doped Calcium Phosphate-Coated Phycocyanin Nanoparticles for Improving the Thermal Stability of Phycocyanin.Foods (Basel, Switzerland) · 2022Article
- Chitosan Covalently Functionalized with Peptides Mapped on Vitronectin and BMP-2 for Bone Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.