ArticleBiosensors & bioelectronics2021
Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva.
Article in Biosensors & bioelectronics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 1 of them a synthesis that pooled it.
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Who cites it
202 citing papers in PubMed, 1 synthesis or guideline pooled it, 433 citations in OpenAlex.
- Electronic and electrochemical viral detection for point-of-care use: A systematic review.PloS one · 2021Pooled it
- Matrix-Guided Size Selection of Plasmonic Nanoprobes for Improving Quantitative Robustness of SERS Lateral Flow Immunoassays.Foods (Basel, Switzerland) · 2026Article
- SARS-CoV-2 Point-of-Care Testing Modalities: Integrating Molecular, Immunological, Biosensor, and AI Approaches.Diagnostics (Basel, Switzerland) · 2026Review
- Extraoral Detection of Biomarkers and Pathogens in Saliva: Comprehensive, Panoramic Review.Biosensors · 2026Review
- A Capacitive Immunosensor Based on a Polypyrrole-CTAB for Probe-Free Detection of SARS-CoV-2 Spike Protein.Micromachines · 2026Article
- An engineered M13 phage-rGO electrochemical biosensor for rapid detection of viral protein in complex matrices.Scientific reports · 2026Article
- High-sensitivity electrochemical immunosensor for anti-SARS-CoV-2 IgG detection using screen-printed carbon/cerium oxide-gold electrode.ADMET & DMPK · 2026Article
- Indium Tin Oxide-Based Voltammetric Biosensor for the Detection of Antibodies Against the SARS-CoV-2 Virus Spike Protein.Sensors (Basel, Switzerland) · 2025Article
- Quantum-enhanced detection of viral cDNA via luminescence resonance energy transfer using upconversion and gold nanoparticles.Nanophotonics (Berlin, Germany) · 2025Article
- Printable Carbon Black/Graphite Conductive Ink toward Electrochemical Determination of Norfloxacin in Environmental Samples.ACS omega · 2025Article
- Stimuli-Responsive Luminophore Drives Mechanism Switch for Highly Efficient Electrochemiluminescence Immunosensing.Journal of the American Chemical Society · 2025Article
- Universal Nanopore Sensor for Amplification-Free and Label-Free Detection of Molecular Biomarkers.ACS sensors · 2025Article
- Low-Cost, Disposable Biosensor for Detection of the Brain-Derived Neurotrophic Factor Biomarker in Noninvasively Collected Saliva toward Diagnosis of Mental Disorders.ACS polymers Au · 2025Article
- A compartmentalization-free microfluidic digital assay for detecting picogram levels of protein analytes.Lab on a chip · 2025Article
- Paper as a Sustainable Material for Smart Electrochemical (Bio)sensors with Unprecedented Features: A Perspective.Analytical chemistry · 2025Review
- Aptamer-enhanced ultrasensitive electrochemical detection of HER-2 in breast cancer diagnosis using ZnO tetrapod-KScientific reports · 2025Article
- Mpox disease, diagnosis, and point of care platforms.Bioengineering & translational medicine · 2025Review
- Carbon black imprinted o-diaminobenzene sensing platform for sensitive electrochemical detection of interleukin 6.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva.ACS sensors · 2025Article
- Enhancing antibiotic detection via an aptasensor: the case of ciprofloxacin.BMC chemistry · 2025Article
142 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diffusion of novel SARS-CoV-2 coronavirus over the world generated COVID-19 pandemic event as reported by World Health Organization on March 2020. The huge issue is the high infectivity and the absence of vaccine and customised drugs allowing for hard management of this outbreak, thus a rapid and on site analysis is a need to contain the spread of COVID-19. Herein, we developed an electrochemical immunoassay for rapid and smart detection of SARS-CoV-2 coronavirus in saliva. The electrochemical assay was conceived for Spike (S) protein or Nucleocapsid (N) protein detection using magnetic beads as support of immunological chain and secondary antibody with alkaline phosphatase as immunological label. The enzymatic by-product 1-naphtol was detected using screen-printed electrodes modified with carbon black nanomaterial. The analytical features of the electrochemical immunoassay were evaluated using the standard solution of S and N protein in buffer solution and untreated saliva with a detection limit equal to 19 ng/mL and 8 ng/mL in untreated saliva, respectively for S and N protein. Its effectiveness was assessed using cultured virus in biosafety level 3 and in saliva clinical samples comparing the data using the nasopharyngeal swab specimens tested with Real-Time PCR. The agreement of the data, the low detection limit achieved, the rapid analysis (30 min), the miniaturization, and portability of the instrument combined with the easiness to use and no-invasive sampling, confer to this analytical tool high potentiality for market entry as the first highly sensitive electrochemical immunoassay for SARS-CoV-2 detection in untreated saliva.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.