Evidence map›Paper›PMID 33085972›Full record

GuidelineJournal of Crohn's & colitis2020

Guidance for Restarting Inflammatory Bowel Disease Therapy in Patients Who Withheld Immunosuppressant Medications During COVID-19.

Corey A Siegel, Britt Christensen, Asher Kornbluth, Joel R Rosh, Michael D Kappelman, Ryan C Ungaro, Douglas Forsyth Johnson, Scott Chapman, David A Wohl, Gerassimos J Mantzaris

Abstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in Journal of Crohn's & colitis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Turkish IBD Organization's Position Statement on Inflammatory Bowel Disease Management Recommendations During COVID-19 Pandemic.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021
    Guideline
  2. Article
  3. Article
  4. COVID-19 induces gastrointestinal symptoms and affects patients' prognosis.The Journal of international medical research · 2022
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Corey A SiegelSection of Gastroenterology and Hepatology, Dartmouth-Hitchcock IBD Center, Lebanon, NH, USA.
Britt ChristensenGastroenterology Department, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Asher KornbluthHenry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joel R RoshDivision of Pediatric Gastroenterology, Goryeb Children's Hospital, Morristown, NJ, USA.
Michael D KappelmanDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ryan C UngaroHenry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Douglas Forsyth JohnsonDepartments of Infectious Diseases and Internal Medicine, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Scott ChapmanDepartment of Infectious Diseases, St Vincent's Hospital, Sydney, NSW, Australia.
David A WohlDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gerassimos J MantzarisDepartment of Gastroenterology, Evaggelismos-Ophthalmiatreion Athinon-Polykliniki GHA, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with inflammatory bowel diseases [IBD] are frequently treated with immunosuppressant medications. During the coronavirus disease 2019 [COVID-19] pandemic, recommendations for IBD management have included that patients should stay on their immunosuppressant medications if they are not infected with the severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], but to temporarily hold these medications if symptomatic with COVID-19 or asymptomatic but have tested positive for SARS-CoV-2. As more IBD patients are infected globally, it is important to also understand how to manage IBD medications during convalescence while an individual with IBD is recovering from COVID-19. In this review, we address the differences between a test-based versus a symptoms-based strategy as related to COVID-19, and offer recommendations on when it is appropriate to consider restarting IBD therapy in patients testing positive for SARS-CoV-2 or with clinical symptoms consistent with COVID-19. In general, we recommend a symptoms-based approach, due to the current lack of confidence in the accuracy of available testing and the clinical significance of prolonged detection of virus via molecular testing.

Indexed as

BetacoronavirusClinical Laboratory TechniquesImmunocompromised HostAsymptomatic InfectionsCoronavirus InfectionsCOVID-19COVID-19 TestingDrug Administration ScheduleHumansImmunosuppressive AgentsInflammatory Bowel DiseasesPandemicsPneumonia, ViralRisk AssessmentSARS-CoV-2Immunosuppressive AgentsbiologicCrohn’sde-escalationIBDimmunomodulator

Identifiers

PMID33085972
PMCPMC7665410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.