Evidence map›Paper›PMID 33085927›Full record

ReviewAnnual review of physiology2021

Temperature Sensation: From Molecular Thermosensors to Neural Circuits and Coding Principles.

Rui Xiao, X Z Shawn Xu

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Accidental hypothermia.Nature reviews. Disease primers · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Cold sensing by a glutamate receptor drives avoidance behavior inbioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Automated analysis ofbioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rui XiaoDepartment of Aging and Geriatric Research, Institute on Aging and Center for Smell and Taste, University of Florida, Gainesville, Florida 32610, USA; email: rxiao@ufl.edu.
X Z Shawn XuLife Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA; email: shawnxu@umich.edu.
University of Florida · USUniversity of Michigan–Ann Arbor · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Neural and genetic mechanisms underlying behavior in C. elegans - Administrative Supplement for Equipment PurchasesR35GM126917 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2018 to 2025
$3.3M
An unexpected role of glutamate receptors in the peripheral nervous systemR01NS118769 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO, XU, SHAWN · 2020 to 2024
$2.6M
Neural and genetic mechanisms underlying mechanosensation in C. elegansR01DC018167 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YE, BING · 2020 to 2025
$2.3M
Dissecting the mechanisms of Alzheimer's disease (AD)-related smell loss in a C. elegans AD modelR01AG063766 · NIA · UNIVERSITY OF FLORIDA · PI XIAO, RUI · 2019 to 2023
$1.9M
Chemosensation and longevity in C. elegansR01AG067753 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2020 to 2024
$1.8M
Identifying novel thermosensitive channels via a high throughput in vivo screenR01NS085798 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2013 to 2016
$1.2M
NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG063766NIA NIH HHS R01 AG067753NIDCD NIH HHS R01 DC018167NIGMS NIH HHS R35 GM126917NINDS NIH HHS R01 NS085798NINDS NIH HHS R01 NS118769
6 · The paper itself

Abstract

Temperature is a universal cue and regulates many essential processes ranging from enzymatic reactions to species migration. Due to the profound impact of temperature on physiology and behavior, animals and humans have evolved sophisticated mechanisms to detect temperature changes. Studies from animal models, such as mouse,

Indexed as

AnimalsHumansNeuronsTemperatureThermosensingcoldheatpainsomatosensationthermoregulationTRP

Identifiers

PMID33085927
PMCPMC7932759
OpenAlexW3093764162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.