Evidence map›Paper›PMID 33085906›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.

Susana Rodriguez, Hannah C Little, Parnaz Daneshpajouhnejad, Paride Fenaroli, Stefanie Y Tan, Dylan C Sarver, Michael Delannoy, C Conover Talbot, Sandeep Jandu, Dan E Berkowitz and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. CTRP10 is required for optimal motor function.The Journal of biological chemistry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. CTRP11 contributes modestly to systemic metabolism and energy balance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Susana RodriguezDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Hannah C LittleDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Parnaz DaneshpajouhnejadDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Paride FenaroliDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Stefanie Y TanDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dylan C SarverDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michael DelannoyDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
C Conover TalbotInstitute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sandeep JanduDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-3931-9372
Dan E BerkowitzDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jennifer L PluznickDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Avi Z RosenbergDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
G William WongDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USNational Institutes of Health · US

Funding

CTRP and Metabolic ControlR01DK084171 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Guang William Wong · 2010 to 2026
$8.0M
Microbial Short Chain Fatty Acids and Blood Pressure RegulationR01HL128512 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2016 to 2020
$2.0M
Uncovering the Functional Role of Olfr78 in Blood Pressure RegulationR01DK107726 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2016 to 2020
$1.8M
Short Chain Fatty Acids (SCFAs) and SCFA G-protein Coupled Receptors in HypertensionR56DK107726 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2021 to 2021
$100k
NHLBI NIH HHS R01 HL128512NIDDK NIH HHS R01 DK084171NIDDK NIH HHS R01 DK107726NIDDK NIH HHS R56 DK107726
6 · The paper itself

Abstract

C1q/TNF-related protein 1 (CTRP1) is an endocrine factor with metabolic, cardiovascular, and renal functions. We previously showed that aged

Indexed as

AdipokinesAge FactorsAgingAnimalsChemokine CCL17Diet, High-FatFemaleGene Expression RegulationGenotypeHypertrophyKidneyKidney DiseasesMaleMiceMice, Inbred C57BLMice, KnockoutAdipokinesCcl17 protein, mouseChemokine CCL17CTRP1 protein, mouseTimp1 protein, mouseTissue Inhibitor of Metalloproteinase-1agingheartkidneymetabolismobesity

Identifiers

PMID33085906
PMCPMC7847058
OpenAlexW3093599644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.