ArticleHuman brain mapping2021
Developmental pattern of the cortical topology in high-functioning individuals with autism spectrum disorder.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Gray matter volume and structural covariance alterations in young males with childhood-onset growth hormone deficiency.BMC medical imaging · 2026Article
- Integrating multi-atlas neuroimaging data for robust biomarker identification in neuropsychiatric disorders.Frontiers in psychiatry · 2026Article
- Cortical Morphology and Morphometric Similarity Network Topology Alterations in Preterm Neonates: Insights From an East Asian Cohort.Human brain mapping · 2025Article
- Insular functional connectivity in autistic and non-autistic development.Biological psychology · 2025Article
- No sex difference in maturation of brain morphology during the perinatal period.Brain structure & function · 2024Article
- Correlation between autistic traits and brain functional connectivity in preschoolers with autism spectrum disorder: a resting state MEG study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Individual Deviation-Based Functional Hypergraph for Identifying Subtypes of Autism Spectrum Disorder.Brain sciences · 2024Article
- 3D CNN for neuropsychiatry: Predicting Autism with interpretable Deep Learning applied to minimally preprocessed structural MRI data.PloS one · 2024Article
- Preterm-birth alters the development of nodal clustering and neural connection pattern in brain structural network at term-equivalent age.Human brain mapping · 2023Article
- Altered Relationship between Functional Connectivity and Fiber-Bundle Structure in High-Functioning Male Adults with Autism Spectrum Disorder.Brain sciences · 2023Article
- Relationship between gray matter structure and age in children and adolescents with high-functioning autism spectrum disorder.Frontiers in human neuroscience · 2022Article
- Sleep medicine: Practice, challenges and new frontiers.Frontiers in neurology · 2022Review
- Altered brain functional network dynamics in classic trigeminal neuralgia: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2021Article
- Developmental pattern of the cortical topology in high-functioning individuals with autism spectrum disorder.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of studies have indicated alterations of brain morphology in individuals with autism spectrum disorder (ASD); however, how ASD influences the topological organization of the brain cortex at different developmental stages is not yet well characterized. In this study, we used structural images of 492 high-functioning participants in the Autism Brain Imaging Data Exchange database acquired from 17 international imaging centers, including 75 autistic children (age 7-11 years), 91 adolescents with ASD (age 12-17 years), and 80 young adults with ASD (age 18-29 years), and 246 typically developing controls (TDCs) that were age, gender, handedness, and full-scale IQ matched. Cortical thickness (CT) and surface area (SA) were extracted and the covariance between cortical regions across participants were treated as a network to examine developmental patterns of the cortical topological organization at different stages. A center-paired resampling strategy was developed to control the center bias during the permutation test. Compared with the TDCs, network of SA (but not CT) of individuals with ASD showed reduced small-worldness in childhood, and the network hubs were reorganized in the adulthood such that hubs inclined to connect with nonhub nodes and demonstrated more dispersed spatial distribution. Furthermore, the SA network of the ASD cohort exhibited increased segregation of the inferior parietal lobule and prefrontal cortex, and insular-opercular cortex in all three age groups, resulting in the emergence of two unique modules in the autistic brain. Our findings suggested that individuals with ASD may undergo remarkable remodeling of the cortical topology from childhood to adulthood, which may be associated with the altered social and cognitive functions in ASD.
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