ArticleBlood transfusion = Trasfusione del sangue2021
Sex-related aspects of the red blood cell storage lesion.
Article in Blood transfusion = Trasfusione del sangue, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
- CD71Scandinavian journal of immunology · 2026Article
- Donor- and unit-specific factors influencing hemolysis in stored canine and feline packed red blood cells.Frontiers in veterinary science · 2026Article
- Manufacturing stresses do not differentially impact red blood cells from donors with diabetes.Vox sanguinis · 2025Article
- Cold storage surpasses the impact of biological age and donor characteristics on red blood cell morphology classified by deep machine learning.Scientific reports · 2025Article
- RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.PLoS computational biology · 2025Article
- Donor age contributes more to the rheological properties of stored red blood cells than donor sex and biological age distribution.Blood advances · 2025Article
- Risk factor assessment of prediabetes and diabetes based on epidemic characteristics in new urban areas: a retrospective and a machine learning study.Scientific reports · 2025Article
- Effects of regular exercise on ischemia-modified albumin and total sulfhydryl levels in young women: a cross-sectional study.Frontiers in physiology · 2025Article
- Genotype-phenotype correlation analysis of patients with thalassemia in quanzhou city, southeast of China.Heliyon · 2024Article
- Article
- Modulation of the allosteric and vasoregulatory arms of erythrocytic oxygen transport.Frontiers in physiology · 2024Review
- Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen.Nature communications · 2023Article
- In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit.Blood transfusion = Trasfusione del sangue · 2023Article
- Red Blood Cell Metabolism In Vivo and In Vitro.Metabolites · 2023Review
- The Effect of the Donor's and Recipient's Sex on Red Blood Cells Evaluated Using Transfusion Simulations.Cells · 2023Article
- Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice.Transfusion · 2023Article
- MicroRNAs as Quality Assessment Tool in Stored Packed Red Blood Cell in Blood Banks.Journal of blood medicine · 2023Review
- Red Blood Cell Donor Sex Associated Effects on Morbidity and Mortality in the Extremely Preterm Newborn.Children (Basel, Switzerland) · 2022Review
- Large Animal Models for Simulating Physiology of Transfusion of Red Cell Concentrates-A Scoping Review of The Literature.Medicina (Kaunas, Lithuania) · 2022Article
- Hypoxic breathing produces more intense hypoxemia in elderly women than in elderly men.Frontiers in physiology · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral factors contribute to the manifestation of red blood cell (RBC) storage lesions, with one of the most interesting being the "donor variation effect". Since many haematological characteristics of blood donors are sex-dependent, sex hormones and their age-dependent variation may affect the storage profile of RBCs. MATERIALS AND
methodsFresh blood from 200 healthy male and female donors underwent haematological, biochemical and physiological analysis. Three selected groups of donors (men, n=8; pre-menopausal women, n=8; and post-menopausal women, n=4) exhibiting as similar as possible baseline values were recruited for blood donation in leukoreduced CPD/SAGM units. RBC indices, haemolysis and propensity for haemolysis, reactive oxygen species (ROS) and plasma antioxidant capacity were measured bi-weekly.
resultsFemale blood was characterised by lower plasma antioxidant capacity and free haemoglobin (Hb) levels in vivo, in spite of the higher RBC osmotic fragility, compared to male blood. Comparatively low Hb concentration was also measured in stored RBCs from female donors, as in vivo. Mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and plasma antioxidant capacity were also lower in female donors throughout storage, even though baseline levels were equal to those of the male group. There was no difference in propensity of stored RBCs for haemolysis between male and female units but intracellular ROS levels were significantly lower in female RBCs. Increased end-of-storage extracellular potassium and recruitment of protein stress markers (clusterin, Hb) to the RBC membrane were observed in the units of post- vs pre-menopausal female donors at mid-storage onwards. DISCUSSION: Donor's sex has an impact on Hb concentration and redox parameters of stored RBCs. In addition, menopause seems to promote RBC membrane remodelling, at least during prolonged storage. Our pilot study provides new insights on the different effects on RBC storage lesion according to sex.
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