Evidence map›Paper›PMID 33085556›Full record

ArticleJournal of neurophysiology2021

Excitation properties of computational models of unmyelinated peripheral axons.

Nicole A Pelot, David C Catherall, Brandon J Thio, Nathan D Titus, Edward D Liang, Craig S Henriquez, Warren M Grill

Erratum issuedAbstract read
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
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  7. Review
  8. Computational modeling of autonomic nerve stimulation: Vagus et al.Current opinion in biomedical engineering · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. NRV: An open framework forbioRxiv : the preprint server for biology · 2024
    Article
  16. The Significance of Concentration-dependent Components in Computational Models of C-Fibers.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023
    Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nicole A PelotDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0003-2844-0190
David C CatherallDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0002-0085-7325
Brandon J ThioDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0002-0136-969X
Nathan D TitusDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0001-8769-2959
Edward D LiangDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0003-4087-1719
Craig S HenriquezDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0002-5395-3767
Warren M GrillDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0001-5240-6588

Funding

ODCDC CDC HHS OT2 OD025340
6 · The paper itself

Abstract

Biophysically based computational models of nerve fibers are important tools for designing electrical stimulation therapies, investigating drugs that affect ion channels, and studying diseases that affect neurons. Although peripheral nerves are primarily composed of unmyelinated axons (i.e., C-fibers), most modeling efforts focused on myelinated axons. We implemented the single-compartment model of vagal afferents from Schild et al. (1994) (Schild JH, Clark JW, Hay M, Mendelowitz D, Andresen MC, Kunze DL.

Indexed as

Action PotentialsModels, NeurologicalAnimalsAxonsNerve Fibers, UnmyelinatedNeurons, AfferentVagus Nerveautonomic nervous systemcomputational modelingunmyelinated axonvagus nervevoltage-gated ion channels

Identifiers

PMID33085556
PMCPMC8087387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.