Evidence map›Paper›PMID 33085486›Full record

ArticleOrganic letters2020

Cyanoamidine Cyclization Approach to Remdesivir's Nucleobase.

Rachel R Knapp, Veronica Tona, Taku Okada, Richmond Sarpong, Neil K Garg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rachel R KnappDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, United States.
Veronica TonaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, United States.
Taku OkadaDepartment of Chemistry, University of California, Berkeley, California 94720, United States.
Richmond SarpongDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-0028-6323
Neil K GargDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, United States.ORCID 0000-0002-7793-2629
University of California, Los Angeles · USUniversity of California, Berkeley · US

Funding

Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical ResearchS10RR025631 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2009 to 2009
$328k
NCRR NIH HHS S10 RR025631
6 · The paper itself

Abstract

We report an alternative approach to the unnatural nucleobase fragment seen in remdesivir (Veklury). Remdesivir displays broad-spectrum antiviral activity and is currently being evaluated in Phase III clinical trials to treat patients with COVID-19. Our route relies on the formation of a cyanoamidine intermediate, which undergoes Lewis acid-mediated cyclization to yield the desired nucleobase. The approach is strategically distinct from prior routes and could further enable the synthesis of remdesivir and other small-molecule therapeutics.

Indexed as

Adenosine MonophosphateAlanineAmidinesAntiviral AgentsChemistry Techniques, SyntheticCoronavirus InfectionsCOVID-19CyclizationPandemicsPneumonia, ViralAdenosine MonophosphateAlanineAmidinesAntiviral Agentsremdesivir

Identifiers

PMID33085486
PMCPMC7653677
OpenAlexW3093603695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.