Evidence map›Paper›PMID 33085465›Full record

ArticleEnvironmental science & technology2020

Comparison of Machine Learning Models for the Androgen Receptor.

Kimberley M Zorn, Daniel H Foil, Thomas R Lane, Wendy Hillwalker, David J Feifarek, Frank Jones, William D Klaren, Ashley M Brinkman, Sean Ekins

Open access · greenAbstract read
In one paragraph

Article in Environmental science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review ofFrontiers in endocrinology · 2022
    Review
  9. Article
  10. Article
  11. Comparing Machine Learning Models for Aromatase (P450 19A1).Environmental science & technology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kimberley M ZornCollaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Daniel H FoilCollaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Thomas R LaneCollaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.
Wendy HillwalkerGlobal Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
David J FeifarekGlobal Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Frank JonesGlobal Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
William D KlarenGlobal Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Ashley M BrinkmanGlobal Product Safety, SC Johnson and Son, Inc., Racine, Wisconsin 53404, United States.
Sean EkinsCollaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.ORCID 0000-0002-5691-5790
SC Johnson (United States) · USCollaborations Pharmaceuticals (United States) · US

Funding

Centralized assay datasets for modelling support of small drug discovery organizationsR44GM122196 · NIGMS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2018 to 2022
$3.3M
MegaTox for analyzing and visualizing data across different screening systemsR43ES031038 · NIEHS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2019 to 2020
$349k
NIEHS NIH HHS R43 ES031038NIGMS NIH HHS R44 GM122196
6 · The paper itself

Abstract

The androgen receptor (AR) is a target of interest for endocrine disruption research, as altered signaling can affect normal reproductive and neurological development for generations. In an effort to prioritize compounds with alternative methodologies, the U.S. Environmental Protection Agency (EPA) used

Indexed as

Machine LearningReceptors, AndrogenAndrogensBayes TheoremProspective StudiesUnited StatesAndrogensReceptors, Androgenandrogen receptorBayesianendocrine disruptionmachine learning

Identifiers

PMID33085465
PMCPMC8243727
OpenAlexW3093818120

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.