Evidence map›Paper›PMID 33085184›Full record

ArticleJournal of cellular and molecular medicine2020

Epigenetic alternations of microRNAs and DNA methylation contribute to gestational diabetes mellitus.

Weiqiang Zhu, Yupei Shen, Junwei Liu, Xiaoping Fei, Zhaofeng Zhang, Min Li, Xiaohong Chen, Jianhua Xu, Qianxi Zhu, Weijin Zhou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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  16. MicroRNAs: key regulators of the trophoblast function in pregnancy disorders.Journal of assisted reproduction and genetics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Weiqiang ZhuKey Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Shandong University, Jinan, China.ORCID 0000-0001-9003-5132
Yupei ShenNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Junwei LiuNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Xiaoping FeiThe First people's Hospital of Kunshan, Kunshan, China.
Zhaofeng ZhangNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Min LiNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Xiaohong ChenDepartment of Obstetrics and Gynecology, Shanghai Pudong New Area Health Care Hospital For Women & Children, Shanghai, China.
Jianhua XuNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Qianxi ZhuNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Weijin ZhouNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Meihua ZhangKey Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Shandong University, Jinan, China.
Shangqing LiuNorth Sichuan Medical College, Nanchong, China.
Jing DuNHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Pharmacy School, Fudan University, Shanghai, China.
Fudan University · CNShandong University · CNJiangsu University · CNNorth Sichuan Medical University · CNPudong Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to identify epigenetic alternations of microRNAs and DNA methylation for gestational diabetes mellitus (GDM) diagnosis and treatment using in silico approach. Data of mRNA and miRNA expression microarray (GSE103552 and GSE104297) and DNA methylation data set (GSE106099) were obtained from the GEO database. Differentially expressed genes (DEGs), differentially expressed miRNAs (DEMs) and differentially methylated genes (DMGs) were obtained by limma package. Functional and enrichment analyses were performed with the DAVID database. The protein-protein interaction (PPI) network was constructed by STRING and visualized in Cytoscape. Simultaneously, a connectivity map (CMap) analysis was performed to screen potential therapeutic agents for GDM. In GDM, 184 low miRNA-targeting up-regulated genes and 234 high miRNA-targeting down-regulated genes as well as 364 hypomethylation-high-expressed genes and 541 hypermethylation-low-expressed genes were obtained. They were mainly enriched in terms of axon guidance, purine metabolism, focal adhesion and proteasome, respectively. In addition, 115 genes (67 up-regulated and 48 down-regulated) were regulated by both aberrant alternations of miRNAs and DNA methylation. Ten chemicals were identified as putative therapeutic agents for GDM and four hub genes (IGF1R, ATG7, DICER1 and RANBP2) were found in PPI and may be associated with GDM. Overall, this study identified a series of differentially expressed genes that are associated with epigenetic alternations of miRNA and DNA methylation in GDM. Ten chemicals and four hub genes may be further explored as potential drugs and targets for GDM diagnosis and treatment, respectively.

Indexed as

DNA MethylationEpigenesis, GeneticGene Expression RegulationComputational BiologyCpG IslandsDatabases, GeneticDiabetes, GestationalDrug DiscoveryFemaleGene Expression ProfilingHumansMicroRNAsPregnancyProtein Interaction MappingRNA InterferenceRNA, MessengerMicroRNAsRNA, MessengerDNA methylationepigeneticsgestational diabetes mellitusmicroRNA

Identifiers

PMID33085184
PMCPMC7753873
OpenAlexW3094331076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.