ArticleCNS neuroscience & therapeutics2021
Deep brain stimulation of the anterior nuclei of the thalamus relieves basal ganglia dysfunction in monkeys with temporal lobe epilepsy.
Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Deep brain stimulation of the anterior nucleus of the thalamus in animal models of mesial temporal lobe epilepsy: A literature review.Epilepsy research · 2025Review
- Alterations of apparent diffusion coefficient from ultra high b-values in the bilateral thalamus and striatum in MRI-negative drug-resistant epilepsy.Epilepsia open · 2024Article
- Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Mapping Lesion-Related Epilepsy to a Human Brain Network.JAMA neurology · 2023Article
- Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.Journal of neuroinflammation · 2023Article
- The adjustment mechanism of the spike and wave discharges in thalamic neurons: a simulation analysis.Cognitive neurodynamics · 2022Article
- Expression of Calbindin, a Marker of Gamma-Aminobutyric Acid Neurons, Is Reduced in the Amygdala of Oestrogen Receptor β-Deficient Female Mice.Journal of clinical medicine · 2022Article
- Revealing the Precise Role of Calretinin Neurons in Epilepsy: We Are on the Way.Neuroscience bulletin · 2022Review
- Long-term music adjuvant therapy enhances the efficacy of sub-dose antiepileptic drugs in temporal lobe epilepsy.CNS neuroscience & therapeutics · 2022Article
- Nucleus accumbens shell modulates seizure propagation in a mouse temporal lobe epilepsy model.Frontiers in cell and developmental biology · 2022Article
- Abnormal hubs in global network as neuroimaging biomarker in right temporal lobe epilepsy at rest.Frontiers in psychiatry · 2022Article
- Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm.CNS neuroscience & therapeutics · 2021Article
- Deep brain stimulation of the anterior nuclei of the thalamus relieves basal ganglia dysfunction in monkeys with temporal lobe epilepsy.CNS neuroscience & therapeutics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDeep brain stimulation of the anterior nuclei of the thalamus (ANT-DBS) is effective in temporal lobe epilepsy (TLE). Previous studies have shown that the basal ganglia are involved in seizure propagation in TLE, but the effects of ANT-DBS on the basal ganglia have not been clarified.
methodsANT-DBS was applied to monkeys with kainic acid-induced TLE using a robot-assisted system. Behavior was monitored continuously. Immunofluorescence analysis and Western blotting were used to estimate protein expression levels in the basal ganglia and the effects of ANT stimulation.
resultsThe seizure frequency decreased after ANT-DBS. D1 and D2 receptor levels in the putamen and caudate were significantly higher in the ANT-DBS group than in the epilepsy (EP) model. Neuronal loss and apoptosis were less severe in the ANT-DBS group. Glutamate receptor 1 (GluR1) in the nucleus accumbens (NAc) shell and globus pallidus internus (GPi) increased in the EP group but decreased after ANT-DBS. γ-Aminobutyric acid receptor A (GABA
conclusionANT-DBS exerts neuroprotective effects on the caudate and putamen, enhances D1 and D2 receptor expression, and downregulates GPi overactivation, which enhanced the antiepileptic function of the basal ganglia.
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