Evidence map›Paper›PMID 33085066›Full record

ArticleNeuromolecular medicine2021

Anti-inflammatory and Cytoprotective Effect of Clinacanthus nutans Leaf But Not Stem Extracts on 7-Ketocholesterol Induced Brain Endothelial Cell Injury.

Xuan Kuo, Deron R Herr, Wei-Yi Ong

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Integrative Wound-Healing Effects ofInternational journal of molecular sciences · 2025
    Article
  4. Antiviral and Immunomodulatory Activities ofInternational journal of molecular sciences · 2023
    Review
  5. Article
  6. Anti-Inflammatory Effects of Phytochemical Components ofMolecules (Basel, Switzerland) · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xuan KuoDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119260, Singapore.
Deron R HerrDepartment of Biology, San Diego State University, San Diego, CA, 92182, USA. dherr@sdsu.edu.ORCID 0000-0001-5755-0896
Wei-Yi OngDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119260, Singapore. antongwy@nus.edu.sg.
National University of Singapore · SGSan Diego State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinacanthus nutans (Lindau) (C. nutans) has diverse uses in traditional herbal medicine for treating skin rashes, insect and snake bites, lesions caused by herpes simplex virus, diabetes mellitus and gout in Singapore, Malaysia, Indonesia, Thailand and China. We previously showed that C. nutans has the ability to modulate the induction of cytosolic phospholipase A

Indexed as

CytoprotectionAcanthaceaeAnti-Inflammatory AgentsBrainCell LineChromatography, High Pressure LiquidCyclooxygenase 2CytokinesDose-Response Relationship, DrugDrug Evaluation, PreclinicalEndothelial CellsGene Expression RegulationHumansKetocholesterolsPlant ExtractsPlant Leaves7-ketocholesterolAnti-Inflammatory AgentsCyclooxygenase 2CytokinesKetocholesterolsPlant ExtractsRNA, MessengerDiabetes mellitusHypercholesterolemiaNeuroinflammationOxysterolsSabah snake grassVascular dementia

Identifiers

PMID33085066
OpenAlexW3094491552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.