Evidence map›Paper›PMID 33084945›Full record

ReviewCellular and molecular life sciences : CMLS2021

Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives.

Paresh Kumar Purohit, Neeru Saini

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. A Distinct Population of Mitochondrial miRNA in Human Male Skeletal Muscle Assessed Before and After Exercise.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  14. Guidelines for mitochondrial RNA analysis.Molecular therapy. Nucleic acids · 2024
    Review
  15. Review
  16. Mitochondrial influences on smooth muscle phenotype.American journal of physiology. Cell physiology · 2024
    Review
  17. Non-Genomic Hallmarks of Aging-The Review.International journal of molecular sciences · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paresh Kumar PurohitFunctional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India.
Neeru SainiFunctional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India. nkhanna@igib.res.in.ORCID http://orcid.org/0000-0002-6986-8372
Institute of Genomics and Integrative Biology · IN

Funding

Council of Scientific and Industrial Research, India BSC0123Council of Scientific and Industrial Research, India FellowshipCouncil of Scientific and Industrial Research, India GENCODE
6 · The paper itself

Abstract

Mitochondria are not only important for cellular bioenergetics but also lie at the heart of critical metabolic pathways. They can rapidly adjust themselves in response to changing conditions and the metabolic needs of the cell. Mitochondrial involvement as well as its dysfunction has been found to be associated with variety of pathological processes and diseases. mitomiRs are class of miRNA(s) that regulate mitochondrial gene expression and function. This review sheds light on the role of mitomiRs in regulating different biological processes-mitochondrial dynamics, oxidative stress, cell metabolism, chemoresistance, apoptosis,and their relevance in metabolic diseases, neurodegenerative disorders, and cancer. Insilico analysis of predicted targets of mitomiRs targeting energy metabolism identified several significantly altered pathways (needs in vivo validations) that may provide a new therapeutic approach for the treatment of human diseases. Last part of the review discusses about the clinical aspects of miRNA(s) and mitomiRs in Medicine.

Indexed as

ApoptosisEnergy MetabolismGene Expression RegulationHumansMicroRNAsMitochondriaMitochondrial DiseasesNeoplasmsOxidative StressMicroRNAsCancerCardiovascular diseaseClinical medicineDiabetesMetabolic disordersmicroRNAmitomiRNeurodegenerative disorders

Identifiers

PMID33084945
PMCPMC11072739
OpenAlexW3094622529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.