SynthesisNeuroradiology2021
Influence of first-pass effect on recanalization outcomes in the era of mechanical thrombectomy: a systemic review and meta-analysis.
Synthesis in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The role of first pass effect in mechanical thrombectomy for vertebrobasilar artery occlusion: a comprehensive meta-analysis of prevalence, outcomes, and predictive factors.Journal of neurointerventional surgery · 2026Pooled it
- Factors Influencing Recanalization After Mechanical Thrombectomy With First-Pass Effect for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Partial (SAVE) versus Complete (Solumbra) Stent Retriever Retraction Technique for Mechanical Thrombectomy: A Randomized In Vitro Study.AJNR. American journal of neuroradiology · 2023Trial
- No-reflow phenomenon after vessel recanalization in acute ischemic stroke: mechanisms, diagnosis, and treatment directions.Journal of neurology · 2026Review
- Development and validation of an explainable machine learning prediction model for futile recanalization after mechanical thrombectomy in acute large vessel occlusion stroke.Journal of neurointerventional surgery · 2026Article
- Clinical Effects of Using the Combined Technique in the First Attempt for Acute Large-vessel Occlusion, with Specific Reference to Age Differences.Neurologia medico-chirurgica · 2026Article
- Progress on using CTA-based vessel distance index to predict futile recanalization: a retrospective observational study.BMC neurology · 2026Observational
- Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke.Drugs & aging · 2025Review
- The use of the NeVa stent-retriever for bail-out mechanical thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- The effect of first pass effect in mechanical thrombectomy for acute terminal internal carotid artery occlusion.European journal of medical research · 2025Article
- Milli-spinner thrombectomy.Nature · 2025Article
- Relationship between first pass effect NLR and PLR in mechanical thrombectomy for acute anterior circulation large-vessel occlusion.Frontiers in neurology · 2025Article
- Development and Evaluation of Non-Antibiotic Growth Promoters for Food Animals.Veterinary sciences · 2024Article
- Endovascular Thrombectomy for Acute Ischemic Stroke : Current Concept in Management.Journal of Korean Neurosurgical Society · 2024Article
- Cost-effectiveness of endovascular treatment for acute ischemic stroke in China: evidence from Shandong Peninsula.Health economics review · 2024Article
- Communicating Arteries and Leptomeningeal Collaterals: A Synergistic but Independent Effect on Patient Outcomes after Stroke.Neurology international · 2024Article
- Influencing factors of futile recanalization after endovascular intervention in patients with acute basilar artery occlusion.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.European stroke journal · 2024Article
- Impact of Successful Recanalization and Clinical Outcomes of Patients With Acute Ischemic Stroke with 5 or More Thrombectomy Passes.Stroke (Hoboken, N.J.) · 2024Article
- Aspiration Versus Stent-Retriever as First-Line Endovascular Therapy Technique for Primary Medium and Distal Intracranial Occlusions: A Propensity-Score Matched Multicenter Analysis.Stroke (Hoboken, N.J.) · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
purposeThis systematic review and meta-analysis summarized the current literature to compare the safety and efficacy between first-pass effect (FPE) and multiple-pass effect (MPE) for thrombectomy in treatment of acute ischemic stroke (AIS).
methodsMajor databases were searched for studies which reported clinical outcomes regarding successful or complete recanalization after first pass of mechanical thrombectomy in AIS. The assessment of bias was performed using different scales. I
resultsA total of 9 studies were eligible for final analysis. For successful recanalization (mTICI 2b-3), favorable outcomes were seen in 49.7% (95% confidence interval (CI): 40.5-58.9%) and 34.7% (95% CI: 26.8-42.7%) of FPE and MPE patients, respectively. Mortality at 3 months was 13.8% (95% CI: 10.8-16.9%) and 26.0% (95% CI: 17.7-34.2%), respectively. For complete recanalization (mTICI 2c-3), proportion of favorable outcomes were 62.7% (95% CI: 51.2-74.2%) and 47.7% (95% CI: 37.4-58.0%) in FPE and MPE; mortality was seen in 11.5% (95% CI: 4.9-18.2%) and 17.0% (95% CI: 5.2-28.7%), respectively. For AIS with successful recanalization, FPE had more favorable outcome (odds ratio (OR): 1.85, 95% CI: 1.48-2.30; p < 0.01; I
conclusionFPE is associated with better outcomes than MPE after achieving successful or complete recanalization.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.