Evidence map›Paper›PMID 33084922›Full record

ArticleWorld journal of urology2021

Prognostic value of pretreatment inflammatory markers in variant histologies of the bladder: is inflammation linked to survival after radical cystectomy?

Severin Rodler, Alexander Buchner, Stephan T Ledderose, Lennert Eismann, Yannic Volz, Paulo Pfitzinger, Alexander Kretschmer, Gerald B Schulz, Alexander Karl, Boris Schlenker and 2 more

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In one paragraph

Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Severin RodlerDepartment of Urology, Klinikum der Universität München, Munich, Germany. severin.rodler@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-7600-6535
Alexander BuchnerDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Stephan T LedderoseDepartment of Pathology, Klinikum der Universität München, Munich, Germany.
Lennert EismannDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Yannic VolzDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Paulo PfitzingerDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Alexander KretschmerDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Gerald B SchulzDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Alexander KarlDepartment of Urology, Krankenhaus Barmherzige Brüder, Marchioninistraße 15, 81377, Munich, Germany.
Boris SchlenkerDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Christian G StiefDepartment of Urology, Klinikum der Universität München, Munich, Germany.
Friedrich JokischDepartment of Urology, Klinikum der Universität München, Munich, Germany.
LMU Klinikum · DEKrankenhaus Barmherzige Brüder · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate differences in standard preoperative inflammatory markers in patients with urothelial carcinoma (UC) and variant histologies undergoing radical cystectomy (RC) and determine its impact on survival.

methodsPatients undergoing RC at an academic high-volume center were retrospectively analyzed. Preoperatively taken CRP, leukocytes, hemoglobin (Hb), and thrombocytes were analyzed as routine inflammatory biomarkers. Log-rank tests and Kruskal-Wallis analysis were used to calculate for differences in survival and in blood levels of biomarkers.

results886 patients with complete follow-up and UC or variant histology underwent RC at our institution between 2004 and 2019. Although variant histology presents with significantly higher t stage than UC, cancer-specific survival (CSS) of UC (1-year-CSS: 93%) is not significantly different to variant histology of UC with squamous differentiation (UCSD, 1-year-CSS: 81%), squamous cell carcinoma (SCC, 1-year-CSS: 82%), and adenocarcinoma (AC, 1-year-CSS: 81%). In UC, alterations in all biomarkers except leukocytes beyond routine cut-off values were associated with poor survival (p < 0.01), whereas Hb beyond cut-off values are associated with poor prognosis in SCC (p < 0.05). CRP levels are significantly elevated in UCSD and SCC at time of surgery compared to UC (p < 0.05).

conclusionInflammatory biomarkers reveal distinctive patterns across UC and variant histologies of bladder cancer. As inflammation might play an important role in cancer progression, further research is warranted to understand those molecular mechanisms and their potential therapeutic impact in variant histology of bladder cancer.

Indexed as

CystectomyAdenocarcinomaAgedBiomarkersCarcinoma, Squamous CellCarcinoma, Transitional CellFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateUrinary Bladder NeoplasmsBiomarkersBiomarkerPatient selectionRadical cystectomyVariant histology

Identifiers

PMID33084922
OpenAlexW3093701889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.