Evidence map›Paper›PMID 33084891›Full record

ArticleThe Journal of infectious diseases2021

Hospitalization Rates and Causes Among Persons With HIV in the United States and Canada, 2005-2015.

Thibaut Davy-Mendez, Sonia Napravnik, Brenna C Hogan, Keri N Althoff, Kelly A Gebo, Richard D Moore, Michael A Horberg, Michael J Silverberg, M John Gill, Heidi M Crane and 17 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. HIV disease in the ICU: an evolving challenge.Proceedings (Baylor University. Medical Center) · 2026
    Article
  8. Article
  9. Article
  10. Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. National Hospitalization Rates and In-Hospital Mortality Rates of HIV-Related Opportunistic Infections in the United States, 2011-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 13 institutions in 3 countries.

Thibaut Davy-MendezGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8505-9268
Sonia NapravnikGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brenna C HoganBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Keri N AlthoffBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Kelly A GeboBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Richard D MooreBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Michael A HorbergKaiser Permanente Mid-Atlantic Permanente Research Institute, Rockville, Maryland, USA.
Michael J SilverbergKaiser Permanente Northern California, Oakland, California, USA.ORCID 0000-0001-9322-1395
M John GillSouthern Alberta HIV Clinic, Calgary, Alberta, Canada.
Heidi M CraneSchool of Medicine, University of Washington, Seattle, Washington, USA.
Vincent C MarconiSchool of Medicine, Emory University, Atlanta, Georgia, USA.
Ronald J BoschT. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Jonathan A ColasantiSchool of Medicine, Emory University, Atlanta, Georgia, USA.
Timothy R SterlingSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
W Christopher MathewsSchool of Medicine, University of California San Diego, San Diego, California, USA.
Angel M MayorSchool of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico, USA.
Ni Gusti Ayu NandithaFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Kate BuchaczDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jun LiDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Peter F RebeiroSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-1951-9104
Jennifer E ThorneSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Ank NijhawanUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
David van DuinSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-4784-3227
David A WohlGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Joseph J EronGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stephen A BerrySchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
North American AIDS Cohort Collaboration on Research and Design of IeDEA
Johns Hopkins University · USUniversity of North Carolina at Chapel Hill · USCenters for Disease Control and Prevention · USKaiser Permanente · USVanderbilt University · USUniversity of Washington · USCentral University of the Caribbean · PRUniversity of California San Diego · USAlberta Hip and Knee Clinic · CAEmory University · USHarvard University · USThe University of Texas Southwestern Medical Center · USUniversity of British Columbia · CA

Funding

Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
WOMEN'S HEALTH AGENDAU01AI038858 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI BENSON, CONSTANCE ANN · 1996 to 2008
$157.5M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
STATISTICAL AND DATA MANAGEMENT CENTERU01AI038855 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HUGHES, MICHAEL DAVID · 1996 to 2006
$78.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Studies of Ocular Complications of AIDS - Coordinating CenterU10EY008057 · NEI · JOHNS HOPKINS UNIVERSITY · PI VAN NATTA, MARK L · 1988 to 2012
$78.0M
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6 · The paper itself

Abstract

backgroundTo assess the possible impact of antiretroviral therapy improvements, aging, and comorbidities, we examined trends in all-cause and cause-specific hospitalization rates among persons with HIV (PWH) from 2005 to 2015.

methodsIn 6 clinical cohorts, we followed PWH in care (≥1 outpatient CD4 count or HIV load [VL] every 12 months) and categorized ICD codes of primary discharge diagnoses using modified Clinical Classifications Software. Poisson regression estimated hospitalization rate ratios for calendar time trends, adjusted for demographics, HIV risk factor, and annually updated age, CD4, and VL.

resultsAmong 28 057 patients (125 724 person-years), from 2005 to 2015, the median CD4 increased from 389 to 580 cells/µL and virologic suppression from 55% to 85% of patients. Unadjusted all-cause hospitalization rates decreased from 22.3 per 100 person-years in 2005 (95% confidence interval [CI], 20.6-24.1) to 13.0 in 2015 (95% CI, 12.2-14.0). Unadjusted rates decreased for almost all diagnostic categories. Adjusted rates decreased for all-cause, cardiovascular, and AIDS-defining conditions, increased for non-AIDS-defining infection, and were stable for most other categories.

conclusionsAmong PWH with increasing CD4 counts and viral suppression, unadjusted hospitalization rates decreased for all-cause and most cause-specific hospitalizations, despite the potential effects of aging, comorbidities, and cumulative exposure to HIV and antiretrovirals.

Indexed as

HIV InfectionsAcquired Immunodeficiency SyndromeAgingAnti-HIV AgentsCanadaCD4 Lymphocyte CountComorbidityHospitalizationHumansRisk FactorsUnited StatesViral LoadAnti-HIV Agentscohort studiesHIVhospitalization

Identifiers

PMID33084891
PMCPMC8205637
OpenAlexW3094555698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.