Evidence map›Paper›PMID 33084573›Full record

ArticleeLife2020

A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells.

Brian L Hua, Florine Em Scholte, Valerie Ohlendorf, Anne Kopp, Marco Marklewitz, Christian Drosten, Stuart T Nichol, Christina Spiropoulou, Sandra Junglen, Éric Bergeron

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  9. Crimean-Congo haemorrhagic fever virus.Nature reviews. Microbiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Brian L HuaCenters for Disease Control and Prevention, Atlanta, United States.ORCID 0000-0002-7580-3399
Florine Em ScholteCenters for Disease Control and Prevention, Atlanta, United States.ORCID 0000-0003-2110-3087
Valerie OhlendorfInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Berlin, Germany.
Anne KoppInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Berlin, Germany.
Marco MarklewitzInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0003-1828-8770
Christian DrostenInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Berlin, Germany.
Stuart T NicholCenters for Disease Control and Prevention, Atlanta, United States.
Christina Spiropoulou *Centers for Disease Control and Prevention, Atlanta, United States.ORCID 0000-0001-8406-3161
Sandra Junglen *Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Berlin, Germany.
Éric Bergeron *Centers for Disease Control and Prevention, Atlanta, United States.ORCID 0000-0003-3398-8628
Centers for Disease Control and Prevention · USGerman Center for Infection Research · DE

Funding

Origin of the innate immunity suppression caused by nairovirus' protease activityR01AI151006 · NIAID · UNIVERSITY OF GEORGIA · PI PEGAN, SCOTT DUSAN · 2020 to 2024
$2.1M
Origin of the innate immunity suppression caused by nairovirus' protease activityR01AI109008 · NIAID · UNIVERSITY OF GEORGIA · PI PEGAN, SCOTT DUSAN · 2014 to 2018
$1.6M
NIAID NIH HHS R01 AI109008NIAID NIH HHS R01 AI151006
6 · The paper itself

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV,

Indexed as

Amino Acid SubstitutionAnimalsArachnid VectorsEuropeGenetic VariationGenome, ViralHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoHumansPhylogenyTickscongo hemorrhagic fever virusinfectious diseasemembrane fusionmicrobiologynairoviridaephylogenetictick-borne virusvirusvirus pathogenesis

Identifiers

PMID33084573
PMCPMC7652417
OpenAlexW3094281761

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.