Evidence map›Paper›PMID 33084572›Full record

ArticleeLife2020

Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus.

Amir Rattner, Chantelle E Terrillion, Claudia Jou, Tina Kleven, Shun Felix Hu, John Williams, Zhipeng Hou, Manisha Aggarwal, Susumu Mori, Gloria Shin and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. The role of Evi/Wntless in exporting Wnt proteins.Development (Cambridge, England) · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Amir RattnerDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0001-9542-6212
Chantelle E TerrillionDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, United States.
Claudia JouDepartment of Physiology and Pharmacology, Robert F. Furchgott Center for Behavioral Neuroscience, State University of New York, Downstate Medical Center, Brooklyn, United States.
Tina KlevenKavli Institute for Systems Neuroscience and Center for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway.
Shun Felix HuDepartment of Physiology and Pharmacology, Robert F. Furchgott Center for Behavioral Neuroscience, State University of New York, Downstate Medical Center, Brooklyn, United States.
John WilliamsDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.
Zhipeng HouDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States.
Manisha AggarwalDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States.
Susumu MoriDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States.
Gloria ShinDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Loyal A GoffDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0003-2875-451X
Menno P WitterKavli Institute for Systems Neuroscience and Center for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-0285-1637
Mikhail PletnikovDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, United States.
André A FentonDepartment of Physiology and Pharmacology, Robert F. Furchgott Center for Behavioral Neuroscience, State University of New York, Downstate Medical Center, Brooklyn, United States.ORCID 0000-0002-5063-1156
Jeremy NathansDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0001-8106-5460
Johns Hopkins University · USState University of New York · USHoward Hughes Medical Institute · USNorwegian University of Science and Technology · NO

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
Neural coordination and discoordination in Fmr1 null miceR01NS105472 · NINDS · NEW YORK UNIVERSITY · PI FENTON, ANDRE ANTONIO · 2017 to 2021
$1.8M
Upgrade of vertical 11.7T MR scannerS10OD023472 · OD · JOHNS HOPKINS UNIVERSITY · PI MORI, SUSUMU · 2017 to 2017
$598k
Howard Hughes Medical InstituteNIH HHS S10 OD023472NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728NIMH NIH HHS R01 MH115304NINDS NIH HHS R01 NS105472
6 · The paper itself

Abstract

In the hippocampus, a widely accepted model posits that the dentate gyrus improves learning and memory by enhancing discrimination between inputs. To test this model, we studied conditional knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop - including nearly all DGCs in the dorsal hippocampus - secondary to eliminating

Indexed as

Avoidance LearningMemorySpatial LearningAnimalsDentate GyrusDisease Models, AnimalFemaleMaleMiceMice, KnockoutMorris Water Maze TestReceptors, G-Protein-CoupledSequence Analysis, RNAGpr177 protein, mouseReceptors, G-Protein-Coupleddentate gyrusdevelopmental biologyhippocampuslearningmemorymouseneuroscience

Identifiers

PMID33084572
PMCPMC7577738
OpenAlexW3094114338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.