Evidence map›Paper›PMID 33084499›Full record

Trial reportNeurorehabilitation and neural repair2020

Gains Across WHO Dimensions of Function After Robot-Based Therapy in Stroke Subjects.

Jennifer Wu, Lucy Dodakian, Jill See, Erin Burke Quinlan, Lisa Meng, Jeby Abraham, Ellen C Wong, Vu Le, Alison McKenzie, Steven C Cramer

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer WuUniversity of California, Irvine, Orange, CA, USA.ORCID 0000-0001-8183-1946
Lucy DodakianUniversity of California, Irvine, Orange, CA, USA.
Jill SeeUniversity of California, Irvine, Orange, CA, USA.
Erin Burke QuinlanUniversity of California, Irvine, Orange, CA, USA.
Lisa MengUniversity of California, Irvine, Orange, CA, USA.
Jeby AbrahamUniversity of California, Irvine, Orange, CA, USA.ORCID 0000-0002-6503-8670
Ellen C WongUniversity of California, Los Angeles, and California Rehabilitation Institute, Los Angeles, CA, USA.ORCID 0000-0002-9519-3655
Vu LeUniversity of California, Irvine, Orange, CA, USA.
Alison McKenzieChapman University, Irvine, CA, USA.
Steven C CramerUniversity of California, Irvine, Orange, CA, USA.ORCID 0000-0002-6214-6211

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Motor Function after StrokeR01NS059909 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C. · 2009 to 2013
$2.0M
Brain plasticity and rehabilitation after strokeK24HD074722 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C. · 2013 to 2017
$588k
NCATS NIH HHS UL1 TR001414NICHD NIH HHS K24 HD074722NINDS NIH HHS R01 NS059909
6 · The paper itself

Abstract

backgroundStudies examining the effects of therapeutic interventions after stroke often focus on changes in loss of body function/structure (impairment). However, improvements in activities limitations and participation restriction are often higher patient priorities, and the relationship that these measures have with loss of body function/structure is unclear.

objectiveThis study measured gains across WHO International Classification of Function (ICF) dimensions and examined their interrelationships.

methodsSubjects were recruited 11 to 26 weeks after hemiparetic stroke. Over a 3-week period, subjects received 12 sessions of intensive robot-based therapy targeting the distal arm. Each subject was assessed at baseline and at 1 month after end of therapy.

resultsAt baseline, subjects (n = 40) were 134.7 ± 32.4 (mean ± SD) days poststroke and had moderate-severe arm motor deficits (arm motor Fugl-Meyer score of 35.6 ± 14.4) that were stable. Subjects averaged 2579 thumb movements and 1298 wrist movements per treatment session. After robot therapy, there was significant improvement in measures of body function/structure (Fugl-Meyer score) and activity limitations (Action Research Arm Test, Barthel Index, and Stroke Impact Scale-Hand), but not participation restriction (Stroke Specific Quality of Life Scale). Furthermore, while the degree of improvement in loss of body function/structure was correlated with improvement in activity limitations, neither improvement in loss of body function/structure nor improvement in activity limitations was correlated with change in participation restriction.

conclusionsAfter a 3-week course of robotic therapy, there was improvement in body function/structure and activity limitations but no reduction in participation restriction.

Indexed as

Outcome Assessment, Health CareSeverity of Illness IndexStroke RehabilitationTherapy, Computer-AssistedAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedParesisRecovery of FunctionRoboticsStrokeWorld Health Organizationclinical trialsoutcomes researchrecoveryrehabilitationstroke

Identifiers

PMID33084499
PMCPMC7704906

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.