Evidence map›Paper›PMID 33084257›Full record

ArticleJournal of biomedical optics2020

Autofluorescence properties of balloon polymers used in medical applications.

Huda Asfour, Jeremy Otridge, Robert Thomasian, Cinnamon Larson, Narine Sarvazyan

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Huda AsfourThe George Washington University, Department of Pharmacology and Physiology, Washington, DC, United States.
Jeremy OtridgeThe George Washington University, Department of Pharmacology and Physiology, Washington, DC, United States.
Robert ThomasianThe George Washington University, Department of Pharmacology and Physiology, Washington, DC, United States.
Cinnamon LarsonNocturnal Product Development, LLC, Durham, North Carolina, United States.
Narine SarvazyanThe George Washington University, Department of Pharmacology and Physiology, Washington, DC, United States.
George Washington University · USNocturnal Product Development (United States) · US

Funding

New generation of catheters for treatment of atrial fibrillationR42HL120511 · NHLBI · NOCTURNAL PRODUCT DEVELOPMENT, LLC · PI SARVAZYAN, NARINE · 2016 to 2017
$2.3M
NHLBI NIH HHS R42 HL120511
6 · The paper itself

Abstract

significanceFor use in medical balloons and related clinical applications, polymers are usually designed for transparency under illumination with white-light sources. However, when illuminated with ultraviolet (UV) or blue light, most of these materials autofluoresce in the visible range, which can be a concern for modalities that rely on tissue autofluorescence for diagnostic or therapeutic purposes.

aimA search for published information on spectral properties of polymers that can be used for medical balloon manufacturing revealed a scarcity of published information on this subject. The aim of these studies was to address this gap. APPROACH: The autofluorescence properties of polymers used in medical balloon manufacturing were examined for their suitability for hyperspectral imaging and related applications. Excitation-emission matrices of different balloon materials were acquired within the 320- to 620-nm spectral range. In parallel, autofluorescence profiles from the 420- to 620-nm range were extracted from hyperspectral datasets of the same samples illuminated with UV light. The list of tested polymers included polyurethanes, nylon, polyethylene terephthalate (PET), polyether block amide (PEBAX), vulcanized silicone, thermoplastic elastomers with and without talc, and cyclic olefin copolymers, known by their trade name TOPAS.

resultsEach type of polymer exhibited a specific pattern of autofluorescence. Polyurethanes, PET, and thermoplastic elastomers containing talc had the highest autofluorescence values, while sheets made of nylon, PEBAX, and TOPAS exhibited negligible autofluorescence. Hyperspectral imaging was used to illustrate how the choice of specific balloon material can impact the ability of principal component analysis to reveal the ablated cardiac tissue.

conclusionsThe data revealed significant differences between autofluorescence profiles of the polymers and pointed to the most promising balloon materials for clinical implementation of approaches that depend on tissue autofluorescence.

Indexed as

HeartPolymersLightingPolymersautofluorescencecatheter designhyperspectral imagingmedical balloons

Identifiers

PMID33084257
PMCPMC7575097
OpenAlexW3093879287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.