Evidence map›Paper›PMID 33084144›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Management of lung transplantation in the COVID-19 era-An international survey.

Benjamin Coiffard, Philipp M Lepper, Eloi Prud'Homme, Florence Daviet, Nadim Cassir, Heinrike Wilkens, Sami Hraiech, Frank Langer, Pascal A Thomas, Martine Reynaud-Gaubert and 4 more

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. COVID-19 and solid organ transplantation: Finding the right balance.Transplantation reviews (Orlando, Fla.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Benjamin CoiffardDepartment of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.ORCID 0000-0002-8896-5346
Philipp M LepperDepartment of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.
Eloi Prud'HommeAix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.
Florence DavietAix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.
Nadim CassirAix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.
Heinrike WilkensDepartment of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.
Sami HraiechAix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.
Frank LangerDepartment of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.
Pascal A ThomasDepartment of Thoracic Surgery, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.
Martine Reynaud-GaubertDepartment of Respiratory Medicine and Lung Transplantation, Aix Marseille Univ, APHM, Hôpital Nord, Marseille, France.
Robert BalsDepartment of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.
Hans-Joachim SchäfersDepartment of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg, Germany.
Laurent PapazianAix Marseille Univ, APHM, Hôpital Nord, Intensive Care Unit, Marseille, France.
Frederik SeilerDepartment of Internal Medicine V - Pneumology, Allergology and Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is unknown if solid organ transplant recipients are at higher risk for severe COVID-19. The management of a lung transplantation (LTx) program and the therapeutic strategies to adapt the immunosuppressive regimen and antiviral measures is a major issue in the COVID-19 era, but little is known about worldwide practice. We sent out to 180 LTx centers worldwide in June 2020 a survey with 63 questions, both regarding the management of a LTx program in the COVID-19 era and the therapeutic strategies to treat COVID-19 LTx recipients. We received a total of 78 responses from 15 countries. Among participants, 81% declared a reduction of the activity and 47% restricted LTx for urgent cases only. Sixteen centers observed deaths on waiting listed patients and eight centers performed LTx for COVID-19 disease. In 62% of the centers, COVID-19 was diagnosed in LTx recipients, most of them not severe cases. The most common immunosuppressive management included a decreased dose or pausing of the cell cycle inhibitors. Remdesivir, hydroxychloroquine, and azithromycin were the most proposed antiviral strategies. Most of the centers have been affected by the COVID-19 pandemic and proposed an active therapeutic strategy to treat LTx recipients with COVID-19.

Indexed as

Lung TransplantationPandemicsCOVID-19HumansImmunosuppressive AgentsRisk FactorsTransplant RecipientsWaiting ListsImmunosuppressive Agentsantibiotic: antiviralclinical research / practiceimmunosuppression / immune modulationimmunosuppressive regimensinfection and infectious agents - viralinfectious diseaselung transplantation / pulmonologyrecipient selectionwaitlist management

Identifiers

PMID33084144
PMCPMC9906357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.