Evidence map›Paper›PMID 33083963›Full record

ArticleMolecular neurobiology2021

Neonatal Serotonin Depletion Induces Hyperactivity and Anxiolytic-like Sex-Dependent Effects in Adult Rats.

Verónica Trujillo, Evandro Valentim-Lima, Rodrigo Mencalha, Quézia S R Carbalan, Raoni C Dos-Santos, Viviane Felintro, Carlos E N Girardi, Rodrigo Rorato, Danilo Lustrino, Luis C Reis and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Verónica TrujilloLaboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu, 862, Edifício de Ciências Biomédicas, 7° andar, Vila Clementino, São Paulo, CEP 04023-062, Brasil.ORCID https://orcid.org/0000-0002-7473-6155
Evandro Valentim-LimaLaboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu, 862, Edifício de Ciências Biomédicas, 7° andar, Vila Clementino, São Paulo, CEP 04023-062, Brasil.ORCID https://orcid.org/0000-0001-9300-7807
Rodrigo MencalhaDepartment of Natural Sciences, Universidade Federal do Acre, Rio Branco, Brazil.ORCID https://orcid.org/0000-0001-9675-754X
Quézia S R CarbalanDepartment of Physiological Sciences, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.
Raoni C Dos-SantosDepartment of Physiological Sciences, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.
Viviane FelintroDepartment of Physiological Sciences, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.ORCID https://orcid.org/0000-0001-6440-6286
Carlos E N GirardiDepartment of Psychobiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1739-6924
Rodrigo RoratoLaboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu, 862, Edifício de Ciências Biomédicas, 7° andar, Vila Clementino, São Paulo, CEP 04023-062, Brasil.ORCID https://orcid.org/0000-0002-1327-9501
Danilo LustrinoDepartment of Physiology, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, Brazil.ORCID https://orcid.org/0000-0001-7118-743X
Luis C Reis *Department of Physiological Sciences, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.ORCID https://orcid.org/0000-0002-1973-6056
André S Mecawi *Laboratory of Neuroendocrinology, Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu, 862, Edifício de Ciências Biomédicas, 7° andar, Vila Clementino, São Paulo, CEP 04023-062, Brasil. mecawi@unifesp.br.ORCID https://orcid.org/0000-0003-4517-6221
Universidade Federal de São Paulo · BRUniversidade Federal Rural do Rio de Janeiro · BRUniversidade Federal de Sergipe · BRUniversidade Federal do Acre · BRUniversidad Nacional de Córdoba · AR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 010239/2016-2Conselho Nacional de Desenvolvimento Científico e Tecnológico 308893/2018-2Conselho Nacional de Desenvolvimento Científico e Tecnológico 423854/2018-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.374200/2019-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/17968-6
6 · The paper itself

Abstract

The serotoninergic system plays an important role in the ontogeny of the mammalian central nervous system, and changes in serotonin production during development may lead to permanent changes in brain cytoarchitecture and function. The present study investigated the programming effects of neonatal serotonin depletion on behavior and molecular components of the serotoninergic system in adult male and female rats. Subcutaneous para-chlorophenylalanine (pCPA) administration (100 mg kg

Indexed as

Sex CharacteristicsAgingAmygdalaAnimalsAnimals, NewbornAnti-Anxiety AgentsBody WeightBrainDorsal Raphe NucleusElevated Plus Maze TestFeeding BehaviorFemaleGene Expression RegulationMaleOpen Field TestParaventricular Hypothalamic NucleusAnti-Anxiety AgentsRNA, MessengerSerotoninAnxietyLocomotionOntogenetic periodpCPAPerinatal programmingSerotonin

Identifiers

PMID33083963
OpenAlexW3093946048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.