Evidence map›Paper›PMID 33083881›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2020

An Unusual Pathway of Mitoptosis Found in Ehrlich Carcinoma Cells.

E A Pimenova, Yu A Reunova, E S Menchinskaya, A A Reunov, D L Aminin

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

E A PimenovaA.V. Zhirmunsky National Scientific Centre of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia. eapimenova@yandex.ru.
Yu A ReunovaA.V. Zhirmunsky National Scientific Centre of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
E S MenchinskayaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690022, Vladivostok, Russia.
A A ReunovA.V. Zhirmunsky National Scientific Centre of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia.
D L AmininG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690022, Vladivostok, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An integrated microscopic study of the destruction of mouse Ehrlich ascites carcinoma (EAC) cells under starvation conditions has been carried out. It has been found that, in addition to apoptosis, necrosis, and apoptotic necrosis, already known for EAC, cell destruction can also occur through mitochondrial autolysis, which is proposed to be considered a new kind of mitoptosis. A mitoptosis in EAC is characterized by the appearance of many autolyzing mitochondria, the fusion of which leads to rupture of the cell membrane and the ejection of the nucleus from the cell. It is assumed that the polymorphism of EAC destruction patterns is explained by the different physiological state of the cells, which determines the "choice" of the cell death mechanism. This situation poses a challenge for researchers to develop complex inducers with the ability to stimulate all possible types of cancer cell death.

Indexed as

AnimalsApoptosisCarcinoma, Ehrlich TumorCell MembraneHumansMetabolic Networks and PathwaysMiceMitochondriaNecrosismitochondriamitoptosismouse Ehrlich ascites carcinoma

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.