Evidence map›Paper›PMID 33083841›Full record

Observational studyBioscience reports2020

Sphingosine-1-phosphate in anti-neutrophil cytoplasmic antibody-associated vasculitis: coagulation-related clinical indicators and complications.

Kai-Li Wu, Qing-Hui Liang, Na Ding, Bo-Wei Li, Jian Hao

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kai-Li WuRenal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China.
Qing-Hui LiangInner Mongolia Medical University, Huhehot, Inner Mongolia 010059, China.
Na DingRenal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China.
Bo-Wei LiRenal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China.
Jian HaoRenal Division, Department of Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhehot, Inner Mongolia 010050, China.
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSphingosine-1-phosphate (S1P) plays a significant role in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

methodsWe collected the plasma samples from 40 patients with AAV and 10 healthy volunteers. The plasma levels of S1P were tested by enzyme-linked immunosorbent assay (ELISA). The levels of serum creatinine (Scr) were tested by rate method, and then the estimated glomerular filtration rate (eGFR) of the patients was calculated from the Scr, age, and gender. Prothrombin time (PT), partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), fibrinogen reduction product (FDP), D-dimer and C-reactive protein (CRP) were tested by turbidimetric inhibition immunoassays. Platelets (PLTs) were tested by fluorescently labeled electrical impedance method.

resultsThe plasma levels of S1P were significantly higher in AAV patients than in healthy volunteers. Correlation analysis showed that plasma levels of S1P were negatively correlated with glomerular filtration (P=0.022, r = -0.306), and positively correlated with circulating levels of Birmingham vasculitis activity score (BVAS), PLT and D-dimer, (P=0.004, r = 0.443; P<0.001, r = 0.654; P=0.006, r = 0.427). The 40 patients with AAV were classified into three groups: the thromboembolism group (with complications of cerebral infarction and myocardial infarction, n=6), cerebral ischemia group (n=4), and cerebral hemorrhage group (n=2). The plasma levels of S1P were highest in the thromboembolism group and lowest in the cerebral hemorrhage group (P=0.003).

conclusionsPlasma levels of S1P were associated with circulating levels of D-dimer, PLT and BVAS in the patients with AAV. Hence, plasma S1P level can be used as a biomarker to predict coagulation-related complications in AAV.

Indexed as

Severity of Illness IndexAgedAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisBiomarkersBlood CoagulationCase-Control StudiesCerebral HemorrhageFeasibility StudiesFemaleFibrin Fibrinogen Degradation ProductsHumansLysophospholipidsMaleMiddle AgedPlatelet CountRisk AssessmentBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DLysophospholipidsSphingosinesphingosine 1-phosphateANCAcoagulation complicationsD-dimerS1Pvasculitis

Identifiers

PMID33083841
PMCPMC7601353
OpenAlexW3093561453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.