Evidence map›Paper›PMID 33083800›Full record

ArticlebioRxiv : the preprint server for biology2020

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2.

Mehdi Baratchian, Jeffrey M McManus, Mike Berk, Fumihiko Nakamura, Sanjay Mukhopadhyay, Weiling Xu, Serpil Erzurum, Judy Drazba, John Peterson, Eric A Klein and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 35 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Mehdi BaratchianGenitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic.
Jeffrey M McManusGenitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic.
Mike BerkGenitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic.
Fumihiko NakamuraGenitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic.
Sanjay MukhopadhyayPathology and Laboratory Medicine Institute, Cleveland Clinic.
Weiling XuDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic.
Serpil ErzurumDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic.
Judy DrazbaImaging Core, Lerner Research Institute, Cleveland Clinic.
John PetersonImaging Core, Lerner Research Institute, Cleveland Clinic.
Eric A KleinDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic.
Ben GastonHerman Wells Center for Pediatric Research, Indiana University School of Medicine.
Nima SharifiGenitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · USIndiana University School of Medicine

Funding

Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2011 to 2020
$26.8M
Elucidating a novel molecular biomarker for castration-resistant prostate cancerR01CA172382 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Nima Sharifi · 2012 to 2026
$5.2M
Clinical Centers for the NHLBI's Precision Interventions for Severe and/or Exacerbation Prone Asthma (PrecISE) Network (UG1)UG1HL139126 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2017 to 2022
$2.4M
Aberrant tumor metabolism that enables AR antagonist-resistant prostate cancerR01CA236780 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHARIFI, NIMA · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA172382NCI NIH HHS R01 CA236780NHLBI NIH HHS P01 HL103453NHLBI NIH HHS UG1 HL139126
6 · The paper itself

Abstract

The sex discordance in COVID-19 outcomes has been widely recognized, with males generally faring worse than females and a potential link to sex steroids. A plausible mechanism is androgen-induced expression of TMPRSS2 and/or ACE2 in pulmonary tissues that may increase susceptibility or severity in males. This hypothesis is the subject of several clinical trials of anti-androgen therapies around the world. Here, we investigated the sex-associated TMPRSS2 and ACE2 expression in human and mouse lungs and interrogated the possibility of pharmacologic modification of their expression with anti-androgens. We found no evidence for increased

Identifiers

PMID33083800
PMCPMC7574256
OpenAlexW3100640716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.