Evidence map›Paper›PMID 33083722›Full record

ArticleiScience2020

Spatially Adaptive Regularization in Total Field Inversion for Quantitative Susceptibility Mapping.

Priya S Balasubramanian, Pascal Spincemaille, Lingfei Guo, Weiyuan Huang, Ilhami Kovanlikaya, Yi Wang

Abstract read
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Priya S BalasubramanianElectrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.
Pascal SpincemailleDepartment of Radiology, Weill Cornell Medicine, New York, NY 10065, USA.
Lingfei GuoDepartment of Radiology, Weill Cornell Medicine, New York, NY 10065, USA.
Weiyuan HuangDepartment of Radiology, Weill Cornell Medicine, New York, NY 10065, USA.
Ilhami KovanlikayaDepartment of Radiology, Weill Cornell Medicine, New York, NY 10065, USA.
Yi WangDepartment of Radiology, Weill Cornell Medicine, New York, NY 10065, USA.

Funding

QSM to Guide Iron Chelating Therapy in Transfusional Iron OverloadR01DK116126 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI BRITTENHAM, GARY M, SHETH, SUJIT · 2019 to 2023
$3.2M
Quantitative Mapping of Substantia Nigra Iron in Parkinson's DiseaseR01NS095562 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHTILBANS, ALEXANDER, WANG, YI · 2016 to 2022
$3.1M
No-Gd MRI for Monitoring Disease Status in Multiple SclerosisR01NS105144 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAUTHIER, SUSAN A, GUPTA, AJAY · 2018 to 2022
$2.8M
Multiple Sclerosis Lesion Magnetic Susceptibility ActivityR01NS090464 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2015 to 2020
$2.3M
3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0M
Compact Representations of Dynamic Liver MRIR01CA181566 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SPINCEMAILLE, PASCAL · 2015 to 2019
$1.9M
NCI NIH HHS R01 CA181566NIDDK NIH HHS R01 DK116126NIH HHS S10 OD021782NINDS NIH HHS R01 NS090464NINDS NIH HHS R01 NS095562NINDS NIH HHS R01 NS105144
6 · The paper itself

Abstract

Adaptive Total Field Inversion is described for quantitative susceptibility mapping (QSM) reconstruction from total field data through a spatially adaptive suppression of shadow artifacts through spatially adaptive regularization. The regularization for shadow suppression consists of penalizing low-frequency components of susceptibility in regions of small susceptibility contrasts as estimated by R2∗ derived signal intensity. Compared with a conventional local field method and two previously proposed regularized total field inversion methods, improvements were demonstrated in phantoms and subjects without and with hemorrhages. This algorithm, named TFIR, demonstrates the lowest error in numerical and gadolinium phantom datasets. In COSMOS data, TFIR performs well in matching ground truth in high-susceptibility regions. For patient data, TFIR comes close to meeting the quality of the reference local field method and outperforms other total field techniques in both clinical scores and shadow reduction.

Indexed as

AlgorithmsMagnetismNuclear Magnetic ResonancePhysics Magnetic Resonance Imaging

Identifiers

PMID33083722
PMCPMC7522736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.