Evidence map›Paper›PMID 33083699›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2020

In-home Compared With In-Clinic Warfarin Therapy Monitoring in Mechanical Heart Valves: A Population-Based Study.

Martin van Zyl, Waldemar E Wysokinski, Thomas M Jaeger, Ana I Casanegra, Bernard J Gersh, Robert D McBane

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Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Martin van ZylDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Waldemar E WysokinskiDivision of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Thomas M JaegerDivision of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Ana I CasanegraDivision of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Bernard J GershDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Robert D McBaneDivision of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate differences in time in therapeutic range (TTR), major bleeding, thromboembolism, and survival comparing in-home and in-clinic international normalized ratio monitoring for patients with mechanical heart valves receiving warfarin anticoagulation. PATIENTS AND

methodsAn observational population-based study of 383 patients (mean ± SD age, 61.5±14.1 years; 38.6% female) with mechanical heart valves (aortic, 77.8%; mitral, 31.1%; tricuspid, 1%; pulmonic 0.2%; and multiple, 9.7%) was performed from January 1, 2012, through December 31, 2017. The target international normalized ratio was 2.5 for 199 patients (52.0%) and 3.0 for 184 (48.0). Of these patients, 37.9% (n=145) were managed by in-home monitoring (cases) and 62.1% (n=238) were monitored in the clinic (controls).

resultsDuring median follow-up of 3.1 years, mean ± SD TTR was similar between in-home (66.6%±19.2%) and in-clinic (67.2%±19.8%) monitoring (

conclusionIn this real-world population-based study of patients with mechanical heart valves, in-home monitoring was equivalent to in-clinic monitoring regarding TTR and important clinical outcomes.

Indexed as

eGFR, estimated glomerular filtration rateHR, hazard ratioINR, international normalized ratioIQR, interquartile rangeLVEF, left ventricular ejection fractionPPY, per person-yearPST, patient self-testingRCT, randomized controlled trialRE-ALIGN, Randomized, Phase II Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients after Heart Valve ReplacementTHINRS, The Home International Normalized Ratio StudyTIA, transient ischemic attackTTR, time in therapeutic range

Identifiers

PMID33083699
PMCPMC7560573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.