Evidence map›Paper›PMID 33083608›Full record

ArticleHeliyon2020

A rationally designed orthogonal synthetase for genetically encoded fluorescent amino acids.

Ximena Steinberg, Jason Galpin, Gibran Nasir, Romina V Sepúlveda, Ernesto Ladron de Guevara, Fernando Gonzalez-Nilo, Leon D Islas, Christopher A Ahern, Sebastian E Brauchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. BeyondChemical reviews · 2025
    Review
  2. Review
  3. Non-canonical Amino Acid Substrates of E. coli Aminoacyl-tRNA Synthetases.Chembiochem : a European journal of chemical biology · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Ximena SteinbergPhysiology Department, Faculty of Medicine, Universidad Austral de Chile, Campus Isla Teja, Valdivia, 5110566, Chile.
Jason GalpinDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United States.
Gibran NasirDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United States.
Romina V SepúlvedaCenter for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Avenida Republica 330, Santiago, Chile.
Ernesto Ladron de GuevaraDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Distrito Federal 04510, Mexico.
Fernando Gonzalez-NiloCenter for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Avenida Republica 330, Santiago, Chile.
Leon D IslasDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Distrito Federal 04510, Mexico.
Christopher A AhernDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, United States.
Sebastian E BrauchiPhysiology Department, Faculty of Medicine, Universidad Austral de Chile, Campus Isla Teja, Valdivia, 5110566, Chile.
University of Iowa · USAustral University of Chile · CLUniversidad Andrés Bello · CLUniversidad Nacional Autónoma de México · MX

Funding

Chemical Biology of Voltage-Gated Sodium and Potassium ChannelsR01GM106569 · NIGMS · UNIVERSITY OF IOWA · PI AHERN, CHRISTOPHER A · 2013 to 2022
$2.7M
Photochemical determination of sodium channel voltage-dependent gating and compositionR01GM122420 · NIGMS · UNIVERSITY OF IOWA · PI AHERN, CHRISTOPHER A · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM106569NIGMS NIH HHS R01 GM122420
6 · The paper itself

Abstract

The incorporation of non-canonical amino acids into proteins has emerged as a promising strategy to manipulate and study protein structure-function relationships with superior precision

Indexed as

Aminoacyl-tRNA synthetaseBiochemistryBioinformaticsBioorganic chemistryCoumarinFluorescenceMolecular biologyProteinsUnnatural amino acids

Identifiers

PMID33083608
PMCPMC7550906
OpenAlexW3092131745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.