Evidence map›Paper›PMID 33083607›Full record

ArticleHeliyon2020

Association of genetic polymorphism at tumor necrosis factor-α gene promoter - 1031T/C and parasitic infections among children in Northern South Africa.

N C Davhana, A K ElBakri, P O Bessong, A Samie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Host genetic backgrounds: the key to determining parasite-host adaptation.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

N C DavhanaMolecular Parasitology and Opportunistic Infection Program, Department of Microbiology, University of Venda, Private Bag X5050, Thohoyandou, 0950, South Africa.
A K ElBakriDepartment of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates.
P O BessongMolecular Parasitology and Opportunistic Infection Program, Department of Microbiology, University of Venda, Private Bag X5050, Thohoyandou, 0950, South Africa.
A SamieMolecular Parasitology and Opportunistic Infection Program, Department of Microbiology, University of Venda, Private Bag X5050, Thohoyandou, 0950, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal parasitic diseases are common in developing countries including South Africa and have been documented to be the most common in children under the age of five. The present study aimed to identify any potential association that may exist between TNF-α promoter gene polymorphism and parasitic infections. A total of 199 blood samples were evaluated from children who were part of the MAL-ED study cohort. The DNA was used to investigate polymorphism in the promoter region of the TNF-α gene at position -1031T/C. The polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The TC genotype at position -1031 was significantly higher in healthy controls children than in children who were infected with

Indexed as

Dzimauli communityGeneticsImmunologyLimpopo provinceMicrobiologyMolecular biologyPCR-RFLPSouth AfricaTNF-α

Identifiers

PMID33083607
PMCPMC7553974

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.