ArticleWellcome open research2019
High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study).
Open access · goldAbstract read
In one paragraph
Article in Wellcome open research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis.The New England journal of medicine · 2025Trial
- Population pharmacokinetics of pyrazinamide and isoniazid in plasma and cerebrospinal fluid from South African adults with tuberculous meningitis.Antimicrobial agents and chemotherapy · 2025Trial
- Safety and Tolerability of a Short Course of Linezolid for the Treatment of Predominantly Moderate to Severe Tuberculous Meningitis in Adults With Human Immunodeficiency Virus.The Journal of infectious diseases · 2025Trial
- Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- New drugs for the management of tuberculosis.Current opinion in infectious diseases · 2025Review
- Etiology and Outcomes of Meningitis among Adults in Three Ugandan Referral Hospitals, 2018-2023: A Prospective Cohort Study in a High-HIV Endemic Setting.The American journal of tropical medicine and hygiene · 2025Observational
- Exposure to Rifampicin and its Metabolite 25-Deacetylrifampicin Rapidly Decreases During Tuberculosis Therapy.Clinical pharmacokinetics · 2025Article
- Experiences, challenges, gaps, and strategies for counselling persons presenting with advanced HIV-associated meningitis in Uganda.AIDS research and therapy · 2025Article
- Advances in the Treatment and Clinical Management Strategies of Tuberculous Meningitis.International journal of general medicine · 2025Review
- A teenage girl with altered mental status and paraparesis.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways.Frontiers in immunology · 2024Review
- Advancing Diagnosis and Treatment in People Living with HIV and Tuberculosis Meningitis.Current HIV/AIDS reports · 2023Review
- Diagnostic and Prognostic Value of Cerebrospinal Fluid Lactate and Glucose in HIV-Associated Tuberculosis Meningitis.Microbiology spectrum · 2022Article
- Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability.Pathogens (Basel, Switzerland) · 2021Review
- Decreased mortality seen in rifampicin/multidrug-resistant tuberculous meningitis treated with linezolid in Shenzhen, China.BMC infectious diseases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 11 institutions in 7 countries.
Suzaan Marais *Department of Neurology, Inkosi Albert Luthuli Central Hospital, Durban, 4091, South Africa.ORCID https://orcid.org/0000-0002-8050-9610
Fiona V Cresswell *Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda.ORCID https://orcid.org/0000-0002-5070-532X
Raph L HamersEijkman-Oxford Clinical Research Unit, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-5007-7896
Lindsey H M Te BrakeDepartment of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Ahmad R GaniemDepartment of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital, Bandung, 40161, Indonesia.
Darma ImranDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia.ORCID https://orcid.org/0000-0002-4109-4192
Ananta BangdiwalaDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID https://orcid.org/0000-0003-0062-9434
Emily MartynInfectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda.
John KasibanteInfectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda.ORCID https://orcid.org/0000-0002-7252-4052
Enock KagimuInfectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda.ORCID https://orcid.org/0000-0002-0291-651X
Abdu MusubireInfectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda.ORCID https://orcid.org/0000-0003-2410-5344
Kartika MaharaniDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia.
Riwanti EstiasariDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia.
Ardiana KusumaningrumDepartment of Microbiology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia.ORCID https://orcid.org/0000-0001-6365-5993
Nadytia KusumadjayantiInfectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia.
Vycke YunivitaDepartment of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital, Bandung, 40161, Indonesia.
Kogieleum NaidooCentre for the AIDS programme of research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Durban, 4041, South Africa.
Richard LessellsCentre for the AIDS programme of research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Durban, 4041, South Africa.ORCID https://orcid.org/0000-0003-0926-710X
Yunus MoosaDepartment of Infectious Diseases, Division of Internal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa.
Elin M SvenssonDepartment of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-0093-6445
Katherine Huppler HullsiekDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.
Rob E AarnoutseDepartment of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
David R BoulwareDivision of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID https://orcid.org/0000-0002-4715-0060
Reinout van CrevelCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-6233-6410
Rovina Ruslami *Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia.
David B Meya *Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda.ORCID https://orcid.org/0000-0002-4138-240X
Mulago Hospital · UGUniversity of Indonesia · IDRadboud University Nijmegen · NLUniversity of Minnesota · USDr. Hasan Sadikin General Hospital · IDPadjadjaran University · IDCentre for the AIDS Programme of Research in South Africa · ZAEijkman Institute for Molecular Biology · IDSouth African Medical Research Council · ZAUniversity of KwaZulu-Natal · ZAUppsala University · SE
Funding
Epidemiology, Immunopathogenesis, and Outcomes of Non-traumatic Spinal Cord Injury in UgandaK43TW010718 · FIC · INFECTIOUS DISEASES INSTITUTE · PI MUSUBIRE, ABDU KISEKKA · 2017 to 2021
$514kFIC NIH HHS K43 TW010718Medical Research Council MR/S004963/1Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
HIVRCTrifampicinTBtreatmentTuberculous MeningitisXpert Ultra
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.